Neurological manifestations of coronavirus disease 19 (COVID-19) such as encephalitis and seizures have been reported increasingly, but our understanding of COVID-19-related brain injury is still limited. Herein we describe prefrontal involvement in a patient with COVID-19 who presented prior anosmia, raising the question of a potential trans-olfactory bulb brain invasion. | e91 LE GUENNEC Et aL.

Emergence of Klebsiella pneumoniae and Salmonella Metallo-Beta-Lactamase (NDM-1) Producers on Reunion Island T he first incident we report here, which occurred on 16 November 2011, involved a 59-year-old French man who was admitted to a Mauritius hospital for decompression sickness. The patient was transferred on 18 November to the French Hospital in the south of Reunion Island. The patient did not receive any antibiotic therapy. In France, patients transferred from a hospital abroad must be screened for multidrug-resistant bacteria (MDR) in the feces. On the day of admission, a rectal screening for MDR was performed on chromID ESBL (extended spectrum ␤-lactamase) medium (bioMérieux, La Balme-Les-Grottes, France). A strain of Klebsiella pneumoniae was isolated, which Vitek Compact testing (bioMérieux) showed to be resistant to imipenem and ertapenem according to the criteria of the European Committee on Antimicrobial Susceptibility Testing. The modified Hodge test (1) with an ertapenem disk was negative for this strain. The isolate was subsequently tested for carbapenemase and ESBL genes by Check-MDR CT102 (2) (Check-Points Health BV, The Netherlands) and was positive for the NDM-1 carbapenemase and CTX-M group 1 ESBL genes. The second incident we report, which occurred on 12 March 2012, involved a 73-year-old French man who was transferred from India to the same unit on Reunion Island. The patient was originally hospitalized in late December 2011 with an intracranial bleed in an Indian hospital (Chennai). On 29 December, the patient was febrile with purulent endotrachealsecretions.AnESBL-producingKlebsiellapneumoniaestrainwas isolated from the patient's sputum. Treatment with unknown antibiotics wasinitiated,buton16January,becausethepatientwasstillfebrile,urine, blood, and endotracheal secretions were cultured. The following bacteria were isolated from these samples: ESBL-producing Escherichia coli (urine) and ESBL-producing Klebsiella pneumoniae (bronchoalveolar lavage [BAL] fluid obtained by blind BAL [mini-BAL]). After recovering, the patient was transferred to Reunion Island. Upon the patient's arrival, a rectal swab was cultured on chromID ESBL medium. Escherichia coli and Klebsiella pneumoniae grew on this medium. An ESBL phenotype was confirmed by a double-disc diffusion synergy test (discs of amoxicillin-clavulanic acid, ceftazidime, cefotaxime, aztreonam, and cefepime). A Salmonella sp. strain resistant to imipenem was isolated from a sample of urine. The serotype of this Salmonella strain was not identified by our common set of working antisera, and the strain was therefore sent to the National Reference Center (CNR E.coli/Shigella/Salmonella; Institut Pasteur, Paris, France). CNR identified Salmonella enterica subsp. enterica serotype Westhampton. This Salmonella strain was also isolated from a second sample of feces after selenite broth enrichment. MICs were determined (Vitek) for the Salmonella strain,andthemodifiedHodgetestwaspositive.Thisstrainwastestedfor carbapenemase genes by Check-MDR CT102 an...

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