No abstract

Enantioselective addition of various aryllithium reagents to aromatic imines was catalyzed (20 mol-%) by readily accessible 1,2-diamines to afford a wide range of protected diarylmethylamines in up to 94 % enantiomeric excess. Furthermore, the absolute configuration of these arylation products was determined by using X-ray crystallography

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Imines. -An efficient arylation of aromatic imines uses a wide diversity of aryllithium reagents activated by chiral 1,2-diamines CDA-1 and CDA-2. Two equivalents of ligand are necessary to obtain good yields and enantioselectivities. However, in some cases substoichiometric amounts (20 mol%) are sufficient to afford diarylmethylamines in up to 94% e.e. By simply changing the imine/organolithium partner, either enantiomer can be produced [cf. (IIIc)]. The absolute configuration of product (VIII) could be established. -(CABELLO, N.; KIZIRIAN, J.-C.; GILLE, S.; ALEXAKIS*, A.; BERNARDINELLI, G.; PINCHARD, L.; CAILLE, J.-C.; Eur.

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