This paper examines a method to estimate aerodynamic parameters, identify the uncertainty in the parameter estimates, and estimate the model form uncertainties from flight test data. This information is required for simulations designed to estimate the reliability of the system. Output error techniques are used in parameter estimation, and uncertainty in these estimates is based on the Cramér-Rao lower bound. The model form uncertainty is estimated based on model validation metrics. The model form uncertainties are used to predict the uncertainty in the aircraft performance and probability of loss of control.

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The differentiation of the fibroblast was followed in the dental pulp of continuously growing incisors of the guinea pig. Based on the ultrastructure, the processes of differentiation of the fibroblasts might be conveniently broken into three stages; Stage I -period of early differentiation, Stage I1 -period of maturation and functioning, and Stage 111 -period of regression.During Stage I the cell had structural characteristics shared by other less differentiated cells. The endoplasmic reticulum was poorly developed, showing vesicular to tubular profiles. The ribosomes were abundant but were mostly distributed in free form. Mitochondria were small and had irregular interiors.Stage I1 was characterized by a striking development of the rough-surfaced endoplasmic reticulum, which appeared in various shapes and sizes. The Golgi complex was enlarged, and contained some fibrillar materials in dilated portions of its membraneous elements. Other features described in the cytoplasm of fibroblasts from other sources were confirmed.Stage III was characterized by the decrease in size and number of various cytoplasmic constituents and was considered to represent cells in the state of regression.

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