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To address a gap between spinal cord injury (SCI) research and practice by rigorously and systematically co-developing integrated knowledge translation (IKT) guiding principles for conducting and disseminating SCI research in partnership with research users. Design: The process was guided by the internationally accepted The Appraisal of Guidelines for REsearch & Evaluation (AGREE) II Instrument for evaluating the development of clinical practice guidelines. Setting: North American SCI research system (ie, SCI researchers, research users, funders). Participants: The multidisciplinary expert panel (nZ17) and end users (nZ35) included individuals from a North American partnership of SCI researchers, research users, and funders who have expertise in research partnerships. Interventions: Not applicable. Main Outcome Measures: Clarity, usefulness, and appropriateness of the principles. Results: Data regarding 125 principles of partnered research were systematically collected from 4 sources (review of reviews, scoping review, interviews, Delphi consensus exercise). A multidisciplinary expert panel held a 2-day meeting to establish consensus, select guiding principles, and draft the guidance. The panel reached 100% consensus on the principles and guidance document. The final document includes a preamble,

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