Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal disorders. Nevertheless, while the clinical characteristics of RAS are well-defined, the precise etiology and pathogenesis of RAS remain unclear. The present article provides a detailed review of the current knowledge of various etiological factors of RAS.

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Objective: To clinically evaluate various tobacco-associated lesions and to evaluate and compare the micronucleus (MN) assay in exfoliated urothelial cells in patients with smoking and smokeless tobacco-associated lesions. Materials and methods:This study was conducted in the Department of Oral Pathology and Microbiology, Mahatma Gandhi Mission's Dental College and Hospital, Navi Mumbai, from October 2012 to June 2013. One hundred cases having tobacco habits (smoking or smokeless) and clinically detectable tobacco-associated lesions were included. Exfoliated urothelial cytosmears were prepared, stained with Papanicolaou and slides were scored for MN.Results: All cases (n = 100) were found to have tobaccoassociated lesions that were clinically detectable. Voided urine samples were collected from all cases (n = 100) who indulged in smoking and smokeless tobacco habit, with males (n = 71) and females (n = 29), whose ages ranged from 19 to 75 years. We observed that out of the 100 cases evaluated, 12 cases showed the presence of MN in the urine cytosmear. Of these 12 cases, n = 10 were bidi smokers and n = 2 were betel quid chewers. Owing to insufficient population of urothelial cells in the cytosmear, MN evaluation could not be statistically proved. Conclusion:Although, MN score in the urothelial cells could not be statistically assessed, due to insufficient number of urothelial cells, our observations reveal that MN count seems to be increased in smokers than smokeless tobacco users. Thus, we urge the need for further studies to highlight the comparative evaluation of MN score between smokers and smokeless tobacco on urothelial cells.

Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, comprising about 15% of all salivary gland tumors and 30% of all salivary malignancies. Most of the MEC arise in the parotid gland. Rarely, it originates in the mandible and maxilla as an intraosseous variant, referred to as ‘central mucoepidermoid carcinoma’ or ‘intraosseous mucoepidermoid carcinoma’. Central mucoepidermoid carcinomas (CMECs) are extremely rare, but well-known entity, comprising 2 to 3% of all MECs reported. Histopathologically, this malignant neoplasm is characterized by mucous, intermediate and epidermoid cells. In this report, we present a case of a male patient diagnosed as low grade CMEC. How to cite this article Iyer JS, Poonja K, Pathak J, Patel S, Poonja L. Low Grade Central Mucoepidermoid Carcinoma. J Contemp Dent 2015;5(1):31-34.

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