wileyonlinelibrary.comnanorods, [ 6,7 ] carbon nanotubes (CNTs), [ 8,9 ] graphene, [ 10,11 ] etc.), have been investigated and developed. Accompany with the development of stimulus-responsive materials, various types of external stimulus, including electric, [ 12,13 ] heat, [14][15][16] light, [ 17,18 ] magnetic, [19][20][21] chemical stimulus, [ 22 ] pneumatic stimulus, [ 23 ] and so forth, have been successfully employed to develop biomimetic or bio-inspired microrobotic systems applying in microjets, [ 16 ] microgrippers, [ 24,25 ] drilling of tissues, [ 26 ] drug and cell delivery, [ 27,28 ] fi xing cancer cells, [ 29 ] artifi cial muscles, [ 30 ] and some other smart microstructures.Because of their ability in wireless/ remote control, low noise, localized driven ability rather than whole-fi eld driven, [ 31 ] light-driven microrobots have attracted more and more attention in novel microbio-robots or micro-motors for biological use. For example, for the minimally invasive medicine applications, the microrobots must exhibit locomotion and controlled interaction with their environment, which should be able to reach a targeted area under the direct supervision and control of an external user. Due to its excellent penetration ability in biological tissues (can be over several centimeters [ 32 ] ), near infrared (nIR) light provides a promising approach to remotely actuate the microrobots in bodies, which may fi nd applications in the development of novel micro-bio-robots or biomimetic micro-motors in vivo and in vitro.Graphene, due to its excellent electrical and thermal conductivity, high surface area, and high fl exibility, has been employed to perform various actuation based on graphene polymeric nanocomposites, that is, stimulated by electrical, [ 33,34 ] electrochemical, [ 11,35 ] and optical energy. [ 10 ] Because of its photothermal effect and high thermal conductivity, graphene and its composites show promising photoresponsive properties. Panchapakesan [ 31 ] reported a large light-induced reversible and elastic response of graphene nanoplatelets (GNPs) polymer composites which is composited with GNPs and polydimethylsiloxane (PDMS), and developed a two-axis submicrometer resolution positioning stage. Wu [ 36 ] developed a bimorph confi guration which was constituted with chemically modifi ed polye thylene (PE) fi lms and a mixture of large-area graphene-chitosan, behaving as a transparent soft actuator that expanded under nIR irradiation. Wang [ 37 ] developed light-driven hand-shape Biomimetic microsystems, which can be driven by various stimuli, are an emerging fi eld in micro/nano-technology and nano-medicine. In this study, a soft and fast-response robotic platform, constituted by PDMS/graphenenanoplatelets composited layer (PDMS/GNPs) and pristine PDMS layer, is presented. Due to the differences in coeffi cient of thermal expansion and Young's modulus of the two layers, the bilayer platform can be driven to bend to the PDMS/GNPs side by light irradiation. The robotic platform (1 mm in width and 7 m...

Lung CFUs also were reduced to the same extent in vaccinated Il18r-/and wild-type mice (Supplemental Figure 7B). In contrast, IL-17-producing T cells recruited to the lungs of IL1r-/mice were reduced, and the mice failed to acquire resistance in comparison with vaccinated wild-type controls. Thus, IL-18R, but not IL-1R, is dispensable in the development of T17 cells and vaccine resistance. Moreover, failed T17 differentiation of 1807 cells in Myd88-/mice is not due to impaired IL-18R signaling, but is likely due to impaired signaling via TLRs and IL-1R. Discussion The fact that adoptively transferred wild-type 1807 cells failed to recruit to the lung in Myd88-/mice and showed a deficit in IL1r-/-, but not Il18r-/-, mice indicates that the deficits in Myd88-/mice are not due to impaired IL-18R signaling, but are likely due to impaired signaling via TLRs and IL-1R.

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Bioinspired soft robotics have unique advantages in superior adaptability and complex motions for field exploration and interaction with humans. The mobility and output force, however, are still the critical challenges for many promising applications. It is attractive to develop “untethered” robotics to improve the mobility by getting rid of the external electrical or pneumatic tethers while achieving massive output stroke and force. Inspired by the creatures' movements induced by the multiplication of cells and asymmetric volume changes of the tissue, an untethered soft actuator composed of self‐contained liquids and super‐elastic chambers is proposed, and by remote stimuli (e.g., near‐infrared light), the capsuled liquids transit from liquid to vapor, giving rise to volume change in the corresponding chambers. Programmable motions, i.e., photophobia of artificial sunflower, can be realized, indicating a massive and linear driving stroke (up to 160% in elongation, 0.5 mm °C−1) and output force (14.5 N with 6 g self‐weight, 0.33 N °C−1). The untethered soft actuator suggests a feasible approach to develop smart, soft, and autonomous robotics and holds promise in fields ranging from surgery to rehabilitation and rescue.

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