The authors observed a relatively high incidence of ROP in this series, especially its severe form affecting relatively more mature infants, which merits further investigation. GA, BW and oxygen therapy were independent ROP determinants.

Introduction: The rejuvenation characteristics of fat tissue grafting has been established for many years. Recently it has been shown that stromal vascular fraction (SVF) of fat tissue contributes to its rejuvenation properties. As the SVF is a minimal processed cell population (based on FDA guidance), therefore it is a suitable cell therapy for skin rejuvenation. This clinical trial was aimed to evaluate the ultrastructural improvement of aging skin in the facial nasolabial region after transplantation of autologous SVF. Methods: Our study was conducted in 16 patients aged between 38 and 56 years old that were interested in face lifting at first. All of the cases underwent the lipoaspiration procedure from the abdomen for sampling of fat tissue. Quickly, the SVF was harvested from 100 mL of harvested fat tissue and then transplanted at dose of 2.0×107 nucleated cells in each nasolabial fold. The changes in the skin were evaluated using Visioface scanner, skin-scanner DUB, Visioline, and Cutometer with multi probe adopter. Results: By administration of autologous SVF, the elasticity and density of skin were improved significantly. There were no changes in the epidermis density in scanner results, but we noticed a significant increase in the dermis density and also its thickness with enrichment in the vascular bed of the hypodermis. The score of Visioface scanner showed slight changes in wrinkle scores. The endothelial cells and mesenchymal progenitors from the SVF were found to chang the architecture of the skin slightly, but there was not obvious phenotypic changes in the nasolabial grooves. Conclusion: The current clinical trial showed the modification of dermis region and its microvascular bed, but no changes in the density of the epidermis. Our data represent the rejuvenation process of facial skin by improving the dermal architecture.

Background:Histopathologic assessment of liver tissue is an essential step in management and follow-up of non-alcoholic fatty liver disease (NAFLD) while inter- and intra-observer variations limit the accuracy of these assessments.Objectives:The aim of this study was to assess the inter- and intra-observer reproducibility of histopathologic assessment of liver biopsies based on NAFLD activity score (NAS) scoring system.Materials and Methods:The anonymous liver biopsy samples of 100 consecutive NAFLD suspected adults were randomly assigned to four pathologists. Then, the samples were randomly reassigned to the pathologists for the second time in a way that each sample would be evaluated by two different pathologists. Biopsies were revisited by their first evaluator after two months. The results were reported based on NAS scoring system.Results:Inter-observer agreement of the pathology scores based on NAS scoring system was acceptable for steatosis, lobular inflammation, and fibrosis, but not for hepatocyte ballooning. The intra-observer agreement was acceptable in all scales, with lowest intra-class correlation observed for lobular inflammation.Conclusions:NAS scoring system has good overall inter- and intra-observer agreement, but more attention should be given to defining the hepatocyte ballooning and lobular inflammation, and training the pathologists to improve the accuracy of pathology reports.

Objectives: Antioxidant treatment with Iron chelating agents is one of the suggested treatments for fatty liver disease, which has become an important health problem in the recent decades. In this study the authors evaluated the general antioxidant, iron chelating, and sugar and fat absorption characteristics of green tea. Methods: Patients with non-alcoholic fatty liver disease were randomly assigned to 2 groups for a double blind clinical trial. Patients in the intervention group received 550 milligrams of green tea tablets daily as well as nutritional education for 3 months. The control group received the same protocol with green tea replaced with placebo tablets. Results: After 3 months, 45 participants (21 in the intervention and 24 in the placebo group) completed the follow-up. The change in body mass index (BMI), aspartate aminotransferase (AST), and fasting blood sugar (FBS) was significantly different between the 2 groups, while the change in total iron binding capacity (TIBC), ferritin, alanine transaminase (ALT), HOMA, and weight did not show a significant difference. Conclusions:The difference between the 2 groups was mainly observed in anthropometrics, liver enzyme, and metabolic indicators, although the difference might not have been highlighted due to the effectiveness of routine treatments, that both groups received.

This article explores the models and frameworks developed on “research impact’. We aim to provide a comprehensive overview of related literature through scoping study method. The present research investigates the nature, objectives, approaches, and other main attributes of the research impact models. It examines to analyze and classify models based on their characteristics. Forty-seven studies and 10 reviews published between 1996 and 2020 were included in the analysis. The majority of models were developed for the impact assessment and evaluation purposes. We identified three approaches in the models, namely outcome-based, process-based, and those utilized both of them, among which the outcome-based approach was the most frequently used by impact models and evaluation was considered as the main objective of this group. The process-based ones were mainly adapted from the W.K. Kellogg Foundation logic model and were potentially eligible for impact improvement. We highlighted the scope of processes and other specific features for the recent models. Given the benefits of the process-based approach in enhancing and accelerating the research impact, it is important to consider such approach in the development of impact models. Effective interaction between researchers and stakeholders, knowledge translation, and evidence synthesis are the other possible driving forces contributing to achieve and improve impact.