It is widely accepted that menopause leads to changes in hormonal status, metabolism and lipid profile. The aim of this study was to analyze the influence of menopause on the concentrations of lipids, lipoproteins and, the influence of estradiol, progesterone, FSH, LH on lipid profile in menopausal women as well. The menopausal women had higher but non-significant (p>0,05) concentrations of total cholesterol, VLDL, LDL, and triglycerides than women with regular menstruation. The concentration of HDL was significantly lower in menopausal women than in women with regular menstruation (p<0,05). Also, the concentration of apolipoprotein B was significantly higher in menopausal women (p<0,05), but the concentrations of apolipoprotein and lipoprotein (a) were lower but without significance (p>0,05). Estrogen concentration has significant negative correlation with VLDL and triglycerides (p<0,05) and significant positive correlation with HDL (p<0,05) in menopausal women. Progesterone concentration has shown no correlation with concentrations of lipids and lipoproteins in menopause. We can conclude that menopause leads to changes in lipid profile by reducing HDL, and elevating apolipoprotein B levels, thus increasing the risk for cardiovascular disease. These changes were caused by reduction of estrogen concentrations in menopause.

SUMMARY -Th e aim of the study was to investigate whether there is diff erence in the quality of life between mothers of children with cerebral palsy and mothers of healthy children, as well as whether the quality of life in mothers of children with cerebral palsy depends on their level of education, child's mobility and child's functional status. A total of 141 mothers participated in the research. Mothers were divided into two groups, 71 mothers of children with cerebral palsy and 70 mothers of healthy children from the Tuzla Canton (Bosnia and Herzegovina). A multidimensional questionnaire PedsQL™ 2.0 Family Impact Mode was used for assessment of the impact of pediatric chronic health condition on the mothers' functioning. Th e level of functional disability of the child was measured by the Gross Motor Function Classifi cation System (GMFCS levels I-V) scale. Mothers of children with cerebral palsy had poorer quality of life than mothers of healthy children in all investigated domains. In relation to mobility of the child, the quality of life was worse in mothers whose children did not move in the area of social functioning in comparison to mothers whose children had the ability to move independently. A statistically signifi cant negative correlation existed between functional status of a child measured with GMFCS and social functioning of mothers, mothers' daily activities, parental functioning, family functioning, and overall quality of life of mothers.

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Glyphosate is a pesticide that infl uences many blood parameters if taken orally or subcutaneously. This pesticide causes important changes in the metabolic activity which can be measured by organospecifi c enzyme activity such as liver aminotransferases (AST and ALT), while glucose acts as a stress, energy and metabolism indicator after acute glyphosate exposure. In this research, glyphosate was applied subcutaneously to rats, administrated each 24 hours for a 15 days period. The concentration of the applied glyphosate was 2.8 g/kg. The experimental rats were 13 weeks old. The concentration of serum glucose, the activity of lactate dehydrogenase and liver transaminases (AST and ALT) were observed as indicators of metabolic changes after treatment. It was observed that glyphosate led to a statistically signifi cant decrease of serum glucose level. Statistically signifi cantly increased (p<0.05) AST, ALT and LDH activities are indicators of hepatocyte damage while LDH activity demonstrates damage of other tissues.

Introduction: Menopause is the absence of menses in the period longer that one year. It is widely accepted that menopause leads to changes in hormonal status, metabolism and lipid profi le. The aim of this study was to analyze the infl uence of menopause on the concentrations of lipids, lipoproteins and also the infl uence of body mass index (BMI) and waist-hip ratio (WHR) on lipid profi le in post-menopausal women. Methods: Sixty post-menopausal women of average age of 52.82 years were compared to a group of 34 pre-menopausal women average age of 47.92 years. Results: Post-menopausal women had higher, but non signifi cant (p>0.05) concentrations of total cholesterol, very low density lipoproteins (VLDL), low density lipoproteins (LDL) and triglycerides than pre-menopausal women. The concentration of high density lipoproteins (HDL) was signifi cantly lower in post-menopausal women than pre-menopausal (p<0.05). The concentration of apolipoprotein B was also signifi cantly higher in post-menopausal women (p<0.05), but the concentrations of apolipoprotein and lipoprotein (a) were lower but without signifi cance (p>0.05). There was no difference between body mass index (BMI) and waste-hip ratio (WHR), but the WHR has shown as a signifi cant predictor of the LDL and cholesterol concentrations in post-menopausal women. Conclusion: We can conclude that menopause leads to changes in lipid profi le by lowering of HDL and increasing the levels of apolipoprotein B, that increases the risk for cardiovascular disease. The WHR is the signifi cant predictor of cardiovascular risk in post-menopausal women.