Background. Tema, Ghana's main industrial city, has many areas that are suspected to be contaminated by lead. Elevated lead levels can affect, among many other issues, mental development, kidney function and blood chemistry. Children are particularly at risk. Objectives. The objective of this study was to determine the concentration of lead in soil from selected sites in Tema and how these levels relate to local pediatric blood lead predictions. Methods. A total of 47 surface soil samples were taken from 9 different sites. Energy dispersive X-ray technique was employed to determine the levels of lead. Pediatric blood lead levels were estimated using the Integrated Exposure Uptake Bio-Kinetic Model For Lead in Children, developed by the U.S. EPA. Results. The study revealed that the selected sites are highly contaminated by lead. In particular, the concentration of Pb in soil at a used lead acid battery recycling facility exceeded regulatory limits for industrial soil as set by the U.S. EPA. The model for predicting concentrations of lead in the blood of age-specific children showed extremely high probabilities of BLLs exceeding regulatory limits. Conclusions. Based on the results of soil testing, sites that were expected to reveal lead exposure positively demonstrated high levels of contamination, in some areas exceeding U.S. and other national regulatory limits. This information is expected to help authorities make informed clean-up decisions.