Pages 10-13 10 www.ijntr.org  Abstract-This study represents one of the earliest studies reporting biological properties (antimicrobial activity, acute toxicity, and phytochemical prospecting) of the aqueous extract of leaves of two plant species, Matayba elaeagnoides Radlk, and Allophylus edulis (A. St. Hilaire, Cambessedes & A. Jussieu) Radlk. ex Warm, both belonging to the Sapindaceae family. Phytochemical prospecting detected the presence of saponins and flavonoids in both species. The acute toxicity test with Artemia salina showed toxicity rates with LC50% of 100mg/mL for Matayba elaeagnoides. Interestingly, none of the extracts showed microbiological activity, using the diffusion disc method against Staphilococus aureus, Escherichia coli and Candida albicans.