• Acoustic radiation force impulse (ARFI) can quantify tissue elasticity of CKD kidney. • Despite standardized measurement, ARFI-estimated elasticity did not correlate with renal fibrosis. • Effects of pathological complexity and tissue perfusion on renal stiffness warrant further study.

In Autonomous Driving (AD), detection and tracking of obstacles on the roads is a critical task. Deep-learning based methods using annotated LiDAR data have been the most widely adopted approach for this. Unfortunately, annotating 3D point cloud is a very challenging, time-and money-consuming task. In this paper, we propose a novel LiDAR simulator that augments real point cloud with synthetic obstacles (e.g., cars, pedestrians, and other movable objects). Unlike previous simulators that entirely rely on CG models and game engines, our augmented simulator bypasses the requirement to create high-fidelity background CAD models. Instead, we can simply deploy a vehicle with a LiDAR scanner to sweep the street of interests to obtain the background point cloud, based on which annotated point cloud can be automatically generated. This unique "scanand-simulate" capability makes our approach scalable and practical, ready for large-scale industrial applications. In this paper, we describe our simulator in detail, in particular the placement of obstacles that is critical for performance enhancement. We show that detectors with our simulated LiDAR point cloud alone can perform comparably (within two percentage points) with these trained with real data. Mixing real and simulated data can achieve over 95% accuracy.

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BackgroundA few studies focused on unilateral or bilateral pedicle screw (PS) fixation of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) to treat lumbar degenerative diseases have been published. There is still debate over whether one method is superior to another. A systematic review and meta-analysis of randomized controlled trials (RCT) was performed to compare the efficacy of the two methods.MethodsWe searched the established electronic literature databases of MEDLINE, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials databases for RCTs comparing the unilateral with bilateral pedicle screw fixation of MIS-TLIF. Pooled mean differences (MD) and odds ratios (OR) and with 95% CIs were calculated for the outcomes.ResultsThree RCTs were identified and analyzed. The results showed that there is no significant difference between the two methods in terms of postoperative VAS-BP score (WMD = -0.09; 95% CI: -0.69 to 0.51; P =0.78), ODI (WMD, -0.09; 95% CI -5.85 to 5.67; P =0.98), fusion rate (OR = 2.99; 95% CI 0.55 to 16.38; P = 0.21) or complication rate (OR = 1.61, 95% CI: 0.49 to 5.37; P =0.43). Unilateral pedicle screw fixation was associated with less blood loss (WMD = -87.83; 95% CI: -160.70 to -14.96; P =0.02).ConclusionsThe existing evidence indicate that no superiority exists between the two fixation methods of MIS-TLIF in terms of functional outcome, fusion rate and complication rate, in spite of that unilateral pedicle screw fixation can achieve less blood loss than bilateral fixation.