pneumonia" OR " coronavirus"), AND " Myocarditis" OR " Cycle threshold (Ct)" OR " Altitude". We found that one article analyzed the risk factors affecting the prognosis of adult patients with COVID-19 in terms of survivorship, without considering Ct values as extrinsic factors.Moreover, there are no reported studies on viral myocarditis caused by COVID-19 and the relationship between the altitude and COVID-19. Added value of this studyWe retrospectively analyzed the clinical data, Ct values, laboratory indicators and imaging findings of 84 adult patients with confirmed COVID-19. Three key-independent risk factors of COVID-19 were identified in our study, including age [OR 2.350; 95% CI (1.206 to 4.580); p=0.012], Ct value [OR 0.158; 95% CI (0.025 to 0.987); p=0.048] and PII [OR 1.912; 95% CI (1.187 to 3.079); p=0.008]. Amongst 84 patients, 13 patients (15.48%) were noted with abnormal electrocardiograms (ECGs) and serum myocardial enzyme levels; whereas 4 (4.8%) were clinically diagnosed as SARS-CoV-2 myocarditis. Moreover, altitude should be considered for COVID-19 severity classification, given that oxygen partial pressure and blood oxygen saturation of regional patients vary with altitudes.

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Soils, as well as most of deformable multiphase porous materials, are likely to suffer from desiccation cracking, leading to the formation of regular crack patterns affecting their permeability. The ensuing crack spacing has often been related to a concept sometimes called ''sequential infilling'': it is assumed that desiccation cracks are formed by successive generations. However, such a concept does not consider the pattern of a simultaneous crack formation at a given moment. Using our desiccation cracking test results and their numerical simulation, we propose a consistent explanation for the formation of desiccation crack patterns in soils. We show that the ''sequential infilling'' concept is suitable only when the position of the crack(s) clearly stems from the stress field. To derive an estimate of the desiccation crack spacing, the overall energy of the system needs to be considered. Statistical variability should be superimposed on the mean deterministic conditions discussed here.

Kawasaki disease (KD) has complexly clinical features and laboratory parameters and there is no definitive biomarker for this disease and the therapy of KD also is complex and uncertain. In this study, 102 KD patients and 80 healthy controls were enrolled in this study and the serum microRNAs were detected by qRT-PCR. The results showed that, compared with KD patients with a good response to high-dose intravenous immunoglobulin (IVIG) therapy, serum miR-200c and miR-371-5p were significantly higher in KD patients with no response to IVIG therapy; compared with KD patients not needing plasma exchange, these two microRNAs were also significantly higher in KD patients needing plasma exchange. In addition, combination of serum miR-200c and miR-371-5p reflected obvious separation between KD patients and healthy controls or between KD patients with no response to IVIG therapy and KD patients with good response to IVIG therapy or KD patients needing plasma exchange and KD patients not needing plasma exchange. Finally, both serum miR-200c and miR-371-5p were also significantly lower in KD under different kinds of therapy. Therefore, serum miR-200c and miR-371-5p have ability as the useful diagnostic biomarkers and therapeutic targets in Kawasaki disease.

Mechanisms of free shrinkage strains of desiccating deformable porous media are studied. The roles of surface evaporation rate, surface tension, and viscosity of pore fluid, soil compressibility and permeability are investigated. For drying tests on two geomaterials with three different pore fluids the evolution of shrinkage strain and fluid content is reported. Most of the strains occur in the saturated phase of drying prior to cracking. Simulations of this phase include evaporative fluxes at the external surfaces, a consequent water transport across the sample toward the surface producing pore pressure and stress gradients, local water content change, and deformation. Biot theory is used.