O objetivo deste estudo retrospectivo de base hospitalar foi descrever as condições de saúde e estimar a sobrevida de 252 pacientes, com diagnóstico prévio de câncer de mama, tratadas e acompanhadas no Ambulatório de Mastologia do Hospital Universitário de Santa Maria, Rio Grande do Sul, Brasil, no período de 1980 a 2000. Para a análise estatística foram utilizados o estimador de Kaplan-Meier e o modelo de Cox. A idade média das pacientes foi 54 anos, sendo que 73,4% apresentaram diagnóstico histológico de carcinoma ductal invasor, 63,9% não apresentaram comprometimento dos linfonodos regionais e 57,6% encontravam-se no estadiamento clínico II. Ao final do estudo, 64,7% das mulheres estavam vivas e sem câncer de mama, e 5,1% morreram por outra causa. A sobrevida estimada em 5 anos, foi de 87,7%, sendo os fatores prognósticos associados: tamanho do tumor (RR = 12,03; > 5cm), comprometimento (RR = 3,08; N1) e número de linfonodos ressecados (RR = 4,66; Nenhum), receptor de estrógeno (RR = 0,34) e c-erbB-2 (RR = 2,51). Com base nos achados deste estudo, destaca-se a importância de ações intensivas de orientação para implementar o rastreamento do câncer de mama, levando a diagnósticos em estádios precoces dessa neoplasia.

In order to better understand the exact mode and risk of vertical transmission in asymptomatic pregnant women, as well as the relationship between HPV transmission and mode of delivery, we have proposed this systematic quantitative review of prospective cohort studies. A comprehensive search was performed in the Cochrane Library, MEDLINE, LILACS, CANCERLIT, and EMBASE, as well as in the reference lists from the identified studies. Nine primary studies, which included 2,111 pregnant women and 2,113 newborns, met our selection criteria and were analyzed. A positive HPV test in the mother increased the risk of vertical HPV transmission (RR: 4.8; 95%CI: 2.2-10.4). We also observed a higher risk of HPV infection after vaginal delivery than after cesarean section (RR: 1.8; 95%CI: 1.3-2.4). The results of this meta-analysis showed the HPV DNA-positive rate only after birth, but an HPV DNA-positive neonatal sample does not necessarily indicate infection; it could merely indicate contamination (perinatal HPV contamination may have occurred). Infants born through vaginal delivery were at higher risk of exposure to HPV.

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We found a high prevalence of HPV DNA in breast cancer. There is strong evidence to suggest that HPV has an important role in the development of breast cancer.