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In modern time the aircraft variants creation is main trend in the aviation industry. One the aspect of the aircraft safety is its safety take-off [1]. The aircraft parameters like relative take-off weight and thrust-to-weight ratio can determine many its performance include take-off. Their influence on decision speed during take-off of modified transport category airplanes are explored. The analytic model is simple and high efficiency way for the first approach of airplane`s safety analyses. The problem is solved by analytics modelling airplane motion on runway during take-off. Quantitative estimation of influence of the airplane weight and thrust-to-weight ratio variation on decision speed of continued or aborted take-off with critical engine failure is given on the base of example of heavy cargo airplane. The application of this way for the airplanes safety analysis is important for each types of aircraft. Estimation model is given in dimensionless parameters and so is applicable for any type of transport category airplanes.