Myo-Inositol and D-chiro-inositol (MI-DCI) are used in the treatment of polycystic ovarian syndrome (PCOS) due to their insulin-sensitizing actions. Therefore, it is of interest to evaluate the treatment patterns, clinical effectiveness and safety of MI-DCI combination in management of PCOS in Indian women .Data from 50 healthcare centers across India between September 2019 and February 2020 were used in the study. Women aged 12-45 years diagnosed with PCOS, who had received MI-DCI (550-150 mg) were included. The outcome parameters were change in weight, luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio, hirsutism, blood glucose and insulin levels, HOMA-IR, and lipid profile. 283 women (mean age: 27.74 years; body mass index: 26.89 kg/m2); of which 197 (69.61%) reported reduction in weight after treatment with MI-DCI. The proportion of hirsutism score reduced after treatment, no hirsutism increased from 31.07% to 50.51% and the severe reduced from 4.85% to zero and moderate from 32.52% to 6.12%. There was a significant reduction in LH:FSH ratio (mean difference: 0.25 mg/dL; p=0.021), free testosterone (mean difference: 1.49; p<0.001) and dehydroepiandrosterone (mean difference: 21.49; P<0.001) levels after regular use of MI-DCI tablets.Treatment with MI-DCI resulted in significant improvement in insulin, HOMA score, FPG, PPG and lipid profile. The therapy restored menstruation and spontaneous ovulation and significantly attenuated the LH/FSH ratio. Thus, MI-DCI (550-150 mg) has shown multidimensional benefits in improving the hormonal, glycemic, and lipid profile of women with PCOS with considerable efficacy and tolerability.

Background: Amniotic fluid is a clear, slightly yellowish liquid that surrounds the fetus during pregnancy. It is contained in the amniotic sac. During pregnancy, it acts as a shock absorber, maintains even temperature, allows for growth and free movement of the fetus and prevents adhesion between fetal parts and amniotic sac. The aim was to study fetal and maternal out come in cases of low AFI and normal AFI. Methods: A hospital based Prospective comparative study was conducted in the Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur from April 2017 to September 2018. Study conducted on 110 pregnant women at term (37-40 weeks) attending antenatal clinic. They were divided in to two groups. Group-A comprising 55 patients with AFI >5 cm and Group-B comprising 55 Patients with AFI less than 5 cm or equal to 5 cm. Results: In our study, Out of 55 oligohydramnios patients, 43.64%(24) were induced, 27.27% (15) were augmented & 29.09%(16) were left for spontaneous progression of labor & out of 55 normal AFI patients 58.18%(32) patients were induced, 29.09%(16) were augmented, 12.73%(7) were left for spontaneous progression of labor. Mean Apgar score at 1 & 5 minute of birth is comparatively low in oligohydramnios patient & nursery admission was more, but only short term neonatal morbidity was seen. No long term consequences were present in these babies. Conclusion: An AFI ≤5 cm detected at term that was at or after 37 completed weeks of gestation in a low risk pregnancy was an indicator of poor perinatal outcome. Oligohydramnios was being detected more frequently nowadays due to ready availability of ultrasonography these days.

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