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ObjectivesTo identify the viral aetiology in adult patients with severe acute respiratory infection (SARI) admitted to sentinel surveillance institutions in Bogotá in 2012.DesignA cross-sectional study was conducted in which microarray molecular techniques for viral identification were used on nasopharyngeal samples of adult patients submitted to the surveillance system, and further descriptions of clinical features and relevant clinical outcomes, such as mortality, need for critical care, use of mechanical ventilation and hospital stay, were obtained.SettingRespiratory infections requiring hospital admission in surveillance centres in Bogotá, Colombia.ParticipantsNinety-one adult patients with acute respiratory infection (55% were female).MeasurementsViral identification, intensive care unit admission, hospital stay, and mortality.ResultsViral identification was achieved for 63 patients (69.2%). Comorbidity was frequently identified and mainly involved chronic pulmonary disease or pregnancy. Influenza, Bocavirus and Adenovirus were identified in 30.8%, 28.6% and 18.7% of the cases, respectively. Admission to the intensive care unit occurred in 42.9% of the cases, while mechanical ventilation was required for 36.3%. The average hospital stay was 9.9 days, and mortality was 15.4%. Antibiotics were empirically used in 90.1% of patients.ConclusionsThe prevalence of viral aetiology of SARI in this study was high, with adverse clinical outcomes, intensive care requirements and high mortality.

Background: Pyogenic granuloma is a kind of inflammatory hyperplasia of multifactorial origin. It is usually related to trauma or constant irritation, drug use and hormonal factors, among others. On the other hand, the odontoma is a benign odontogenic tumor composed of epithelial and mesenchymal cells. Its development is usually associated with trauma, infections, inherited disorders or odontoblast hyperactivity. Objective: To present the clinical case of a patient with pyogenic granuloma associated with the presence of a mandibular odontoma, its therapeutic management and postoperative results. Case report: The case presents a 32-year-old female patient with a history of multinodular goiter and hypothyroidism who developed a mandibular odontoma on the left side, which was also associated with a pyogenic granuloma in the same area. It was treated with surgical excision and the affected tissues were reconstructed with lyophilized bone and collagen membrane. Favorable outcome was seen after surgery without evidence of recurrence and with proper osseointegration of alloplastic materials and soft tissues. Conclusions: The irritant effect of a tumor (odontoma) in developing a pyogenic granuloma was confirmed.

<p>Background. Multiplex real time PCR is increasingly used to diagnose respiratory viruses and has shown to be superior to traditional methods, such as culture and antigen detection. Objective. Standardization and validation of a multiplex real-time PCR assay for the detection of 13 respiratory viruses. Methods. The assay was validated using RNA control targets and comparing results to single-target PCR’s. Results. Using RNA controls the multiplex format was found to be as sensitive and specific as the single-target PCRs, and no competition was observed between targets. The efficiencies for most of the reactions were approximately 90%, but a lower efficiency was found for Parainfluenza 2 with a rate of amplification in each cycle of 86.63%. On the other hand, a higher efficiency was observed in respiratory syncytial virus A and respiratory syncytial virus B ((93.07% each). Conclusion: This multiplex RT-PCR format shows an adequate efficiency, demonstrating an excellent sensitivity, specificity and repeatability for all the studied respiratory viruses.</p>

Parkinsonismo inducido por cleboprida Palabras clave: Cleboprida. Síndrome de Parkinson. Reacciones adversas a medicamentos.