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• TSR is a recognized independent prognostic factor in many solid tumours. • D and f values measured by IVIM MRI are independently correlated with TSR while D* is not. • IVIM offers the potential to predict TSR.

A gap existed between the medical staff's clinical practice and the preferences of the cancer patients and their families. The medical staff should receive adequate training in cancer communication skills and techniques for improvement in this respect. When designing training for skills in delivering bad news to cancer patients, the well-being of cancer patients and their families must be thoroughly considered, and patient demands for information should be satisfied in the context of the information explosion of the current age.

Background The identification of hypoxia inducible factor (HIF‐1α) expression is helpful for the quantitative assessment of tumor hypoxia. The application of multimodal imaging techniques may play a part in the assessment of HIF‐1α expression of cervical carcinoma. Purpose To investigate the correlations between multiple imaging parameters and HIF‐1α expression of early cervical carcinoma and to determine whether tumor hypoxia can be predicted using multisequence imaging parameters. Study Type Prospective observational. Population One hundred patients with early cervical carcinoma. Field Strength/Sequences 3.0 T MRI including intravoxel incoherent motion (IVIM) diffusion‐weighted imaging (DWI) and dynamic contrast‐enhanced (DCE) perfusion MRI sequences. Assessment DCE‐MRI and IVIM DWI were performed for all patients. The imaging parameters included volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular volume fraction (Ve), D, D*, and f. Statistical Tests The comparisons of imaging parameters between two independent groups were performed using the Mann–Whitney U‐test. Multiple linear regression analysis was performed to determine the correlation between multiple imaging parameters and HIF‐1α expression. The diagnostic ability of DCE‐MRI, IVIM DWI, and the combination of two techniques for discriminating high‐expression and low‐expression groups were analyzed. Results The high‐expression group had a lower Ktrans or Kep value than the low‐expression group (P = 0.03; 0.02), while the high‐expression group had a higher Ve value than the low‐expression group (P = 0.03). The high‐expression group had a higher D or f value than the low‐expression group (P = 0.02; 0.02). Ktrans, Kep, D, Ve, and f values were independently correlated with HIF‐1α expression. The sensitivity or accuracy of a combined method was higher than that of DCE‐MRI or IVIM DWI individually (P = 0.03, 0.02; 0.04, 0.03). Data Conclusion The combination of DCE‐MRI and IVIM DWI can improve the diagnostic ability of discriminating different HIF‐1α expression levels for early cervical tumors. Level of Evidence: 1 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:918–929.

Naringenin (Nari) has antioxidative and anti-atherosclerosis effects, and activation of ATP-sensitive potassium channel (KATP) can offer cardiac protection. We hypothesized that Nari protects the heart against ischemia–reperfusion (I–R) injury through activation of KATP. Isolated hearts from adult male Sprague-Dawley rats experienced a 30-min global ischemia followed by 60-min reperfusion (120 min for the infarct size determination). The hearts were treated with Nari (NARI); Nari plus glibenclamide (GLI), a non-specific ATP-sensitive potassium channel blocker (NARI+GLI); and Nari plus 5-hydroxy decanoic acid (5-HD), a mitochondrial membrane ATP-sensitive potassium channel blocker (NARI+5-HD). The left ventricular pressure, lactate dehydrogenates (LDH) in coronary effluent, superoxide dismutase (SOD) and malondialdehyde (MDA) in myocardium, and myocardial infarct area were measured. Nari above 2.5 μmol/L improved the recovery of left ventricular function, decreased LDH in coronary effluent, and reduced myocardial infarct area. The SOD activity was increased and MDA was decreased in Nari-treated myocardium. The cardioprotective effect of Nari was canceled by GLI and 5-HD. In conclusion, Nari has a cardioprotective effect against I–R injury, which may be carried out through activating ATP-sensitive potassium channels in both cell and mitochondrial membrane, and enhancing myocardial antioxidant capacity.