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The uncertainty relation is regarded as a remarkable feature of quantum mechanics differing from the classical counterpart, and it plays a backbone role in the region of quantum information theory. In principle, the uncertainty relation offers a nontrivial limit to predict the outcome of arbitrarily incompatible observed variables. Therefore, to pursue a more general uncertainty relations ought to be considerably important for obtaining accurate predictions of multi-observable measurement results in genuine multipartite systems. In this article, we derive a generalized entropic uncertainty relation (EUR) for multi-measurement in a multipartite framework. It is proved that the bound we proposed is stronger than the one derived from Renes et al. in [Phys. Rev. Lett. 103,020402(2009) ] for the arbitrary multipartite case. As an illustration, we take several typical scenarios that confirm that our proposed bound outperforms that presented by Renes et al. Hence, we believe our findings provide generalized uncertainty relations with regard to multi-measurement setting, and facilitate the EUR’s applications on quantum precision measurement regarding genuine multipartite systems.