Dengue fever (DF) and dengue haemorrhagic fever (DHF), an infection disease who still become a health problem in Indonesia. There was increasing cases reported in Indonesia from 2011 to 2012. Thrombocytopenia and plasma leakage signed by haemoconcentration are important indicator in dengue. Bleeding manifestation appears as clinical symptom of DF and DHF that increases mortality ratio of dengue infection. The aim of this study is toinvestigatethe correlation of thrombocytopenia and hematocrit tobleeding manifestation of dengue fever and dengue haemorrhagic fever.This study is retrospective cross-sectional. Forty two men and thirty five women were evaluated in this study, fifty nine of them were diagnosedas DF and eighteen of them were diagnosed asDHF. The correlation of thrombocytes to hematocrit used nonparametric Spearman test, the result were significant with p=0,000 and r=-0,183. The correlation of thrombocytes to the occurrence of bleeding manifestation and hematocrit to the occurrence of bleeding manifestation, both were not significant, with p=0,714 and p=0,153. This study suggest that there were a very weak correlation between thrombocytes and hematocrit and no correlation between thrombocytopenia and hematocrit with bleeding manifestation. Keywords: Dengue Fever, Dengue Haemorrhagic Fever, Thrombocytopenia, Hematocrit, and Bleeding Manifestation.   Abstrak: Demam dengue (DD) dan demam berdarah dengue (DBD) merupakan penyakit infeksi yang masih menjadi masalah kesehatan di Indonesia. Telah dilaporkan terdapat peningkatan jumlah kasus di Indonesiadari tahun 2011 ke tahun 2012. Berdasarkan kriteria laboratorium WHO, jumlah trombosit yang rendah (trombositopenia) dan kebocoran plasma yang ditandai dengan hemokosentrasi merupakan indikator penting pada DD dan DBD. Gejala klinis DD dan DBD dapat disertai dengan manifestasi perdarahan yang akan meningkatkan rasio mortalitas penderita infeksi dengue. Penelitian yang bertujuan untuk mengetahui hubungan trombositopenia dan hematokrit dengan manifestasi perdarahan pada penderita demam dengue dan demam berdarah dengue ini menggunakanmetode retrospektif dengan studi cross-sectional.Sampel pada penelitian ini terdiri dari 42 orang laki-laki dan 35 orang perempuan. Penderita DD berjumlah 59 orang dan penderita DBD berjumlah 18 orang. Uji nonparametrik Spearman terhadap trombosit dan hematokrit mendapat hasil signifikan (p=0,000 ; r=-0,183). Uji nonparametrik Spearman terhadap trombosit dan manifestasi perdarahan mendapat hasil yang tidak signifikan (p=0,714). Uji nonparametrik Spearman terhadap hematokrit dan manifestasi perdarahan mendapat hasil yang tidak signifikan (p=0,153). Dapat disimpulkan bahwa terdapat korelasi yang sangat lemah antara trombosit dan hematokrit, tidak terdapat hubungan yang bermakna antara trombositopenia dan hematokrit dengan manifestasi perdarahan. Kata kunci:Demam Dengue, Demam Berdarah Dengue, Trombositopenia, Hematokrit, dan Manifestasi Perdarahan.

The objective of this study is to determine the correlation between anemia and quality of life in chronic kidney disease patients undergoing regular hemodialysis. This was an observational analytical study with a cross-sectional design. Samples were obtained by using consecutive sampling. Patients’ quality of life was assessed with short-form 36 questionnaires (SF-36) while their Hb levels data were taken from the medical records. There were 60 samples, with a majority age range of 50-59 years old (33.33%) adn the dominant gender was males (68,3%). There were 13 non-anemia patients (22%), 27 mild anemia patients (45.0%), 15 moderate anemia patients (25.0%) and 5 severe anemia patients (8%). The highest quality of life score obtained was 90.70 with an average score 61.99. The Spearman correlation test showed a correlation between anemia and life quality (p=0.000). Conclusion: There was a significant correlation between anemia and quality of life in chronic kidney disease patients undergoing regular hemodialysis.Keywords: chronic kidney disease, hemodialysis, anemia, quality of life Abstrak: Tujuan dari penelitian ini untuk mengetahui hubungan anemia dengan kualitas hidup pasien PGK yang sedang menjalani hemodialisis reguler. Desain penelitian yang digunakan adalah analitik observasional dengan rancangan studi potong silang (cross sectional study). Teknik pengambilan sampel yang digunakan yaitu consecutive sampling. Data kualitas hidup pasien diukur dengan pertanyaan dalam kuesioner Short Form (SF-36) sedangkan kadar Hb diambil dari rekam medik. Hasil dari penelitian ini didapatkan sampel 60 orang, usia terbanyak 50-59 tahun (33,3%), jenis kelamin terbanyak adalah laki-laki (68,3%), tidak anemia 13 orang (22%), anemia ringan 27 orang (45,0%), 15 orang (25,0%) anemia sedang dan sisanya 5 orang (8%) anemia berat. Skor kualitas hidup tertinggi 90,70 dengan rata-rata 61,99. Uji korelasi spearman didapatkan hubungan antara anemia dengan kualitas hidup (p=0,000). Simpulan: Terdapat hubungan yang signifikan antara anemia dengan kualitas hidup pasien PGK yang sedang menjalani hemodialisis reguler.Kata kunci: penyakit ginjal kronik, hemodialisis, anemia, kualitas hidup

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Background CKD Patients on routine hemodialysis (HD) are prone to medical complications and conditions that are potentially detrimental to the quality of life (QoL), such as anemia, malnutrition, low body mass index (BMI), HD shift time, and HD adequacy measured by Kt/V. CKD patients undergoing routine HD mostly have lowered QoL and are at higher risk for malnutrition, inflammation, hospitalization, and mortality, compared to the general population. This study intends to find out whether there is a correlation between these factors and the quality of life of patients undergoing routine hemodialysis. Methods The design of this study is a cross-sectional analysis of observational data. Hemodialysis patients from general hospital Prof. dr. R. D. Kandou Manado for 3 months from August to October 2017 were included. Fifty-two patients meet the inclusion and exclusion criteria. The correlation between quality of life with anemia, serum albumin, BMI, adequacy of HD, using Pearson correlation test (if normality test fulfilled) or Spearman correlation test (if the normality test not fulfilled) and Independent Samples T-test to assess the quality of life with HD shift time. Results This study found no correlation between hemoglobin levels (p=0.244, r=-0.098), BMI (p=0.473, r=-0.010), HD timing (p=0.082) and quality of life of the patients, but a significant correlation between serum albumin (p=0.020, r=0.286), HD adequacy measured by Kt/V (p=0.030, r=0.257) and subjects' quality of life. Conclusion This study showed that serum albumin and Kt/V values had a significant correlation with quality of life, while hemoglobin, BMI and dialysis shift time are not related to the quality of life.

Acute coronary syndrome (ACS) is a series of clinical disorders caused by acute ischemic heart disease, including angina unstable, non-ST elevation myocardial infarction, and ST-elevation myocardial infarction. This study aimed to determine the relationship of routine hematological changes with the course of acute coronary syndromes. We used a descriptive method. Data were obtained from the secondary data of ACS patients in the ICCU RSUP Prof. Dr. R. D. Kandou Manado during 2010. The data were presented in distributive tables. The results showed that most patients did not experience decreases in hematological parameters such as hemoglobin, hematocrite, erythrocyte counts, and platelet counts. The leucocyte counts increased in 50% of cases. Conclusion: In general, there was no decrease in hematological parameters, except leukocyte counts, among the ACS patients in the ICCU RSUP Prof. Dr. R. D. Kandou Manado during 2010. Keywords: acute coronary syndrome, coronary heart disease, hematology, inflammation Abstrak: Sindrom koroner akut (SKA) merupakan rangkaian gangguan klinis yang disebabkan oleh penyakit akut iskemik jantung, termasuk angina tidak stabil, non-ST elevasi miocard infraction, dan ST-elevasi miocard infraction. Penelitian ini bertujuan untuk mengetahui hubungan perubahan hematologi rutin dengan perjalanan penyakit sindrom koroner akut. Penelitian ini memakai metode deskriptif dengan menggunakan data sekunder dari penderita SKA di ruang ICCU RSUP Prof. Dr. R. D. Kandou Manado selama tahun 2010. Data hasil penelitian disajikan dalam bentuk tabel distributif. Hasil penelitian  memperlihatkan bahwa sebagian besar pasien tidak memperlihatkan penurunan parameter hematologi. Jumlah leukosit meningkat pada 50% kasus. Simpulan: Umumnya tidak terdapat penurunan parameter hematologi, kecuali jumlah leukosit pada pasien SKA ruang ICCU RSUP Prof. Dr. R. D. Kandou Manado selama tahun 2010. Kata kunci: Sindrom koroner akut, penjakit jantung koroner, Hematologi, inflamasi