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Topical retinoids are currently approved by the US Food and Drug Administration for the treatment of acne vulgaris in nonpregnant, nonlactating patients 12 years of age and older. Their efficacy, safety, and tolerability are well documented for inflammatory and noninflammatory acne with studies repeatedly demonstrating a decrease in the number of lesions, significant improvement in acne severity, improvement in the cosmetic appearance of acne, and the prevention of acne lesions through microcomedone formation. There is some variability between prescription retinoid products regarding efficacy, safety, and tolerability; with erythema, peeling, and dryness being common, potential side effects. Due to their efficacious and safe profile, topical retinoids remain the first-line treatment for acne vulgaris.

Toys are a reflection of the compounds used frequently in manufacturing. Allergic contact dermatitis to potties, metal toys, and children's jewelry is well known, however, there is a broad range of skin risks in toys. With the objective to identify and publicize the associated risk of contact dermatitis in children's toys, we have searched the PubMed database from creation to September 9, 2019. Studies were eligible if they reported a new case of contact dermatitis secondary to interaction with a toy in patients from birth to 18 years of age. A toy was defined as something children interact with for entertainment during leisure time. In this review of the PubMed database we filtered by age and language which may have prevented us from detecting cases in adults that could be extrapolated to children. In addition, several articles were excluded based on title alone. A total of 1312 articles were identified and reviewed manually for inclusion criteria. Review of the articles found 25 original articles for consideration. Several toys were found to be associated with contact dermatitis. These included electronics, toy cars, costume jewelry, bicycles, sqwish balls, slime, Play-Doh, and plasticine. Electronics such as video game controllers, cellphones, iPads, and computers were implicated. In conclusion, there is still an unmet need for observation of this segment of industry for labeling of contents and ongoing surveillance.

Background There is an increasing interest in and demand for noninvasive anti‐aging treatments, and cosmeceuticals are an effective adjunct treatment to in‐office cosmetic treatments. Objective This study evaluates the short‐term cosmetic benefits of a topical anti‐wrinkle cream (Ultrascript Dermal Regenesis, Montclair, NJ) and a topical evening DNA repair serum (Dermal DNA Repair Serum with the active ingredient AC‐11 from Optigenex INC). Methods Fourteen women of all Fitzpatrick skin types were randomized to receive either the topical anti‐wrinkle cream (AM cream) only or the AM cream and the topical evening DNA repair serum (PM serum) for 16 weeks. Subjects noted their subjective improvement in wrinkles, pore size, hyperpigmentation, and overall skin quality. Two blinded physicians evaluated the appearance of wrinkles pre‐ and postapplication of the AM cream. Results Participants who applied the AM cream only reported subjective improvement in wrinkles and overall quality of their skin. Immediate improvement of wrinkles was seen after the application of the AM cream. Subjects who applied both the AM cream and PM serum noted improvement in pore size. Conclusion This novel anti‐wrinkle cream is a safe and effective topical treatment for the immediate, but short‐term improvement of wrinkles. Prolonged use of the cream and continued follow‐up may show additional long‐term benefits.

Background There are many postprocedure skin care options, but no consensus on the best formulation to optimize healing. Silicone gels have only been used to treat keloids and hypertrophic scars and typically applied after the wound has healed. This study compared the healing response after fractional ablative erbium laser resurfacing with a petrolatum‐based ointment and a silicone gel. Methods A randomized, open‐label, split‐face study was performed. Ten subjects underwent Erbium:YAG (Sciton) fractional laser resurfacing. Patients were randomized to apply a petrolatum‐based gel or a silicone gel (Stratacel®; Stratpharma) on either the right or left side of the face. Subjects applied the products twice a day for 7 days and were evaluated in person 7, 30, and 60 days postprocedure. Subjects reported on the overall general aesthetic outcome, perceived pain, itch, and tightness via questionnaires using the Global Aesthetic Improvement Scale and the Wrinkle Severity Rating Scale (WSRS). Results All subjects healed without complications. By day 60, there was no difference in signs and symptoms of healing between the two different dressing approaches. However, patients treated with the silicone gel had less post‐treatment erythema and hyperpigmentation. Conclusions A novel silicone gel resulted in reduced signs of erythema and hyperpigmentation postprocedure, without an increase in adverse events. Additionally, the silicone gel dries to form a thin, full contact film and can be covered with sunscreen or cosmetics once dry. This new silicone gel presents a good option for postprocedure care after ablative fractional laser resurfacing.