No abstract

Tower crane accidents frequently occur in the construction industry, often resulting in casualties. The utilization of tower cranes involves multiple phases including installation, usage, climbing, and dismantling. Moreover, the hazards associated with the use of tower cranes can change and be propagated during phase alternation. However, past studies have paid less attention to the differences and hazard propagations between phases. In this research, these hazards are investigated during different construction phases. The propagation of hazards between phases is analyzed to develop appropriate safety management protocols according to each specific phase. Finally, measures are suggested to avoid an adverse impact between the phases. A combined method is also proposed to identify hazard propagation, which serves as a reference and contributes to safety management and accident prevention during different tower crane phases in the construction process.

Vegetation phenology and its spatiotemporal driving factors are essential to reflect global climate change, the surface carbon cycle and regional ecology, and further quantitative studies on spatiotemporal heterogeneity and its two-way driving are needed. Based on MODIS phenology, meteorology, land cover and other data from 2001 to 2019, this paper analyzes the phenology change characteristics of the Yangtze River Delta from three dimensions: time, plane space and elevation. Then, the spatiotemporal heterogeneity of phenology and its driving factors are explored with random forest and geographic detector methods. The results show that (1) the advance of start of season (SOS) is insignificant—with 0.17 days per year; the end of season (EOS) shows a significant delay—0.48 days per year. The preseason temperature has a greater contribution to SOS, while preseason precipitation is main factor in determining EOS. (2) Spatial differences of the phenological index do not strictly obey the change rules of latitude at a provincial scale. The SOS of Jiangsu and Anhui is earlier than that of Zhejiang and Shanghai, and EOS shows an obvious double-clustering phenomenon. In addition, a divergent response of EOS with elevation grades is found; the most significant changes are observed at grades below 100 m. (3) Land cover (LC) type is a major factor of the spatial heterogeneity of phenology, and its change may also be one of the insignificant factors driving the interannual change of phenology. Furthermore, nighttime land surface temperature (NLST) has a relatively larger contribution to the spatial heterogeneity in non-core urban areas, but population density (PD) contributes little. These findings could provide a new perspective on phenology and its complex interactions between natural or anthropogenic factors.

The wide spread of antibiotic-resistant "superbugs" containing New Delhi metallo-β-lactamase-1 (NDM-1) has become a threat to human health. However, clinically valid antibiotics to treat the superbugs' infection are not available now. Quick, simple, and reliable methods to assess the ligandbinding mode are key to developing and improving inhibitors against NDM-1. Herein, we report a straightforward NMR method to distinguish the NDM-1 ligand-binding mode using distinct NMR spectroscopy patterns of apo-and di-Zn-NDM-1 titrations with various inhibitors. Elucidating the inhibition mechanism will aid the development of efficient inhibitors for NDM-1.