Nanocarrier-based biological°uorescent probes for ketamine and amphetamine have been prepared by conjugating red and green°uorescent nanoparticles (150-nm-sized) with anti-ketamine and anti-amphetamine antibodies, respectively, with the assistance of carbodiimide/N-hydroxysuccinimide. Biological°uorescent probes for ketamine and amphetamine could simultaneously detect these two drugs within a single¯ngermark by one-step test. Nanoparticles as carrier played dual-functional roles for not only¯ngermark visualization but also drug recognition. Latent ngermarks were visualized by the°uorescence signal generated from nanoparticles. The developed¯ngermarks clearly revealed ridge pattern and su±cient minutiae for individual identi¯cation. Ketamine and amphetamine were recognized by simply observing the colors of°u orescent images when the¯ngermark was checked in red and green channels. Detection limit of ketamine or amphetamine was 50 ng in¯ngermark. This work therefore provides a novel nanocarrier-based strategy of drug detection as well as personal identi¯cation with high selectivity, low background interference and fast testing, which can be further broadened to other drugs and molecules.

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Size-controlled hematite mesocrystals were prepared by forced hydrolysis of FeCl3via a facile hydrothermal process.

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