As a type of unique gaseous molecules, SO2 presents capabilities in the feasible cellular influx and the induction of apoptosis by generating intracellular toxic radicals. Developing therapeutic platforms to enable effective SO2 gas release at the tumor site is highly demanded in the exploration of more “green” and effective treatment protocols for cancer therapy but remains challenging. Here for the first time, fine nanosheets composing of Mg‐Al layered double hydroxides (MgAl LDH) are synthesized and inserted with sulfite in its layered structures (MgAl‐SO3 LDH). After the loading of glucose oxidase (GOx/MgAl‐SO3 LDH), the composite nanosheets present the controllable SO2 gas release in an acidic responsive manner. Owing to the glycolysis effect of GOx, the gluconic acid generated agitates the intracellular SO2 release from nanosheets, and excessive H2O2 reacts with SO2 effectively and facilitates the production of toxic radicals, inducing remarkable oxidative damages to tumor cells. Meanwhile, the consumption of intracellular glucose by GOx/MgAl‐SO3 LDH depletes the energy supply of tumor cells, favoring the tumor inhibition both in vitro and in vivo in a synergistic fashion. Therefore, this study has provided distinctive perspectives in the exploration of therapeutic platforms with green functionalities and biodegradability for effective tumor treatment.

Fine nanocapsules based on MnFe hydroxides, showing high loading capacity, O2 induction and biodegradation, were synthesized for effective synergistic therapies.

Cellular starvation induced by glucose oxidase (GOx) had been extensively explored as a potential approach for tumor therapy. However, the therapeutic efficacy suffers daunting challenges due to the unsatisfactory intracellular transportation of GOx molecules. Herein for the first time, hydroxide nanoparticles with unique hollow microstructure (denoted as H-NiAl(OH)x) were designed and synthesized for GOx delivery. In this system, despite its intrinsic degradation properties in acidic tumor microenvironment, Ni2+ ions released during degradation may catalyze a Fenton reaction to induce considerable production of cytotoxic hydroxyl radicals (OH). The cavity of hollow nanocapsules provides large surface area, and favors GOx capsulation and delivery. The findings indicate the intracellular glucose can be effectively consumed by GOx transported, and the reaction products consisting of acid and H2O2 facilitate the OH induction of nanocapsules in a synergistic manner. Both in vitro and in vivo antitumor properties have been consequently achieved by H-NiAl(OH)x/GOx systems. This study offering catalytic nanocapsules based on Ni2+ ions may spark a series of follow-on explorations in constructing drug delivery and therapeutic systems for synergistic tumor treatment.

In this study, fine hollow nanocapsules, consisting of NiFe hydroxides (denoted as H-NiFe(OH)x), are designed and synthesized for the delivery of anticancer drug (Doxorubicin, DOX) and tumour depletion. Owing to...