Objective: To investigate the effect of Sandwich Learning (SL) in the theory teaching of Histology and Embryology. Methods: 110 freshmen majoring in clinical medicine were randomly chosen as the experimental group of Sandwich Learning, while 111 students at the same grade were chosen as the control group for traditional lecture-style teaching. After different teaching, students from both groups were surveyed by questionnaires. And they had to take examinations about theoretical knowledge and specimen of Histology and Embryology. Then the same group of teachers marked all the exam papers according to the same scoring standards. Results: There were significantly differences in the averages of the final exam about theoretical knowledge, regular assignments and final scores between two groups. Difference in results of specimen assessment was not statistically significant. The questionnaire survey results showed that students affirmed the effect of sandwich learning in improving learning initiative, sense of responsibility and communication skills in study. Conclusion: The research shows that the application of Sandwich Learning has good teaching effect in theory teaching of Histology and Embryology and helps to cultivate the comprehensive ability of medical students.

In the era of Internet plus, thanks to the popularity of mobile terminals, it is quick and convenient for people to get information and knowledge. The mobile learning mode of WeChat official account assisted teaching provides students with an independent learning platform, which combines information technology and classroom teaching. As an expansion and extension of the traditional classroom, it can cultivate the independent learning ability of students and promoted students to change from "passive learning" to "active learning". Taking WeChat official account as an example, we will explore the teaching mode of "Internet plus Education" and discuss the construction of learner-centered, online and offline education ecology based on WeChat official account. In addition, we hope to provide some reference for the teaching reform of "Internet plus Education" mode in our country.