The uptake of iodide into the thyroid, an essential step in thyroid hormone synthesis, is an active process mediated by the sodium-iodide symporter (NIS). Despite its strong dependence on TSH, the master regulator of the thyroid, the NIS gene was also reported to be regulated by non-TSH signaling pathways. In the present study we provide evidence that the rat NIS gene is subject to regulation by sterol regulatory element-binding proteins (SREBPs), which were initially identified as master transcriptional regulators of lipid biosynthesis and uptake. Studies in FRTL-5 thyrocytes revealed that TSH stimulates expression and maturation of SREBPs and expression of classical SREBP target genes involved in lipid biosynthesis and uptake. Almost identical effects were observed when the cAMP agonist forskolin was used instead of TSH. In TSH receptor-deficient mice, in which TSH/cAMP-dependent gene regulation is blocked, the expression of SREBP isoforms in the thyroid was markedly reduced when compared with wild-type mice. Sterol-mediated inhibition of SREBP maturation and/or RNA interference-mediated knockdown of SREBPs reduced expression of NIS and NIS-specific iodide uptake in FRTL-5 cells. Conversely, overexpression of active SREBPs caused a strong activation of the 5'-flanking region of the rat NIS gene mediated by binding to a functional SREBP binding site located in the 5'-untranslated region of the rat NIS gene. These findings show that TSH acts as a regulator of SREBP expression and maturation in thyroid epithelial cells and that SREBPs are novel transcriptional regulators of NIS.

The authors investigated the impact of video speed on judging the duration of sport performance. In three experiments, they investigated whether the speed of video presentation (slow motion vs. real time) has an influence on the accuracy of time estimation of sporting activities (n1 = 103; n2 = 100; n3 = 106). In all three studies, the time estimation was more accurate in real time than in slow motion, in which time was overestimated. In two studies, the authors initially investigated whether actions in slow motion are perceived to last longer because the distance they cycled or ran is perceived to be longer (n4 = 92; n5 = 106). The results support the hypothesis that the duration of sporting activities is estimated more accurately when they are presented in real time than in slow motion. Sporting officials’ judgments that require accurate time estimation may thus be biased when based on slow-motion displays.

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The implicit motivational needs for power, achievement, and affiliation are relevant for sports performance. Due to their hypothesized association with functions of the right hemisphere (McClelland, 1986), they may influence lateralized perceptual and motor processes. And due to their interactions with motive-specific incentives, they may influence performance conditional on the presence of suitable incentives. This preregistered study, conducted mostly online, examines motivational needs using a standard picture-story exercise (PSE) and their associations with indicators of perceptual and motor laterality and sports performance in gymnasts (N = 67). Further it explores how implicit motives interact with suitable motivational incentives in the prediction of sports performance. Results partly confirm a link between indicators of cerebral rightward laterality and implicit motives: the implicit affiliation and achievement motives are positively associated with an indicator of emotional-perceptional laterality (chimericfaces task), but not with an indicator of motor laterality (turning bias). Moreover, the implicit achievement motive was positively correlated with training hours. The implicit affiliation motive was negatively associated with the highest attained competition level. The presence of achievement incentives (perceived control, failure) and affiliation incentives (training together or alone) did not interact with corresponding motives to predict sports performance.