Solubility data for several A"-substituted sulfonamides in water and in chloroform at 298.15 K and derived Gibbs energies of transfer of these drugs from water to chloroform are reported. Stability constants, derived Gibbs energies, enthalpies and entropies of complexation of these drugs with P-cyclodextrin as obtained by titration microcalorimetry in water are given.Gibbs energy data are used to evaluate the effect of P-cyclodextrin on the transfer of the drug from water to chloroform. It is concluded that the process of transfer of the drug in this solvent system is thermodynamically more favoured in the absence of cyclodextrin.
SYNOPSISThe chemical structure of an aliphatic epoxy resin was studied by using gel permeation chromatography (GPC), Fourier transform infrared (FTIR), FTIR-TGA (thermogravimetric analysis), mass spectrometry in fast atom bombardment (FAB) mode, and wet analysis.We found that when trimethylolpropane is used as starting monomer, only two OH groups are epoxidized. The resin and its different fractions have a functionality of two. Under the conditions of synthesis used by the supplier, three main products were found with masses of 246, 339, and 430. No trifunctional product was detected. 0 obtained is low, and the reaction practically stops when T g , = Tc if Tg, < Tg, (vitrification).
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