No abstract

Seaweeds have been a food source since ancient times (600 BC) and are still widely used in Asia, mainly in traditional Chinese medicine and Japanese folk medicine. Nowadays, seaweed compounds and extracts have been gaining interest from the biomedical and pharmaceutical market sectors. Seaweeds have been referenced as feasible solutions in finding new potential compounds and therapies in prevention, control, and reduction of cancer development due to the multirole of some bioactive components (e.g, phenolic compounds and sulphated polysaccharides). Moreover, seaweeds are rich in important health-promoting molecules [such as poly and highly unsaturated fatty acids (PUFAs and HUFAs), essential amino acids, vitamins, and dietary fibers] and minerals (calcium, iron, iodine, magnesium, phosphorus, potassium, zinc, copper, manganese, selenium, and fluoride). In this review, the potential therapeutic effects of seaweed in the prevention and treatment of cancer are approached, as well as nutraceutical properties of seaweed to promote cell homeostasis.

Springer Nature terms of use for archived accepted manuscripts (AMs) of subscription articles, books and chapters can be found at: https://www.springernature.com/gp/open-research/ policies/accepted-manuscript-terms 1 Tissues and industrial co-products formed during alginate extraction from Laminaria hyperborea provide different metabolite profiles depending on harvest season

In this work, Hydrophilic Interaction Liquid Chromatography – Mass Spectrometry (HILIC-MS) was applied to assess the metabolic profiles of different tissues and industrially relevant co-products of alginate extraction from Laminaria hyperborea samples obtained in different seasons. This is the first metabolomic analysis in L. hyperborea and it allowed the putative identification of 59 metabolites using positive and negative mode MS data, predicted exact mass data and matching with database and literature searches. Another 16 components were detected but these could not be identified as yet. The metabolites ranged from known and abundant components (e.g., iodide, mannitol and various betaines) to components not previously noted in this species. The levels of these components varied between tissues and co-products with some metabolites seemingly specific to certain samples. The components also varied between winter and summer samples, perhaps reflecting seasonality in their biosynthesis and accumulation in the tissues and co-products.Therefore, the method can be used to survey the seasonal metabolomic variation across the full year and thereby track when components of potential specific commercial interest were maximally accumulated and help plan the most efficient exploitation of the harvested biomass. The method could also define variation in components in L. hyperborea from different locations or potential biotopes of this species. This initial work extends our ability to understand the phenotype of seaweeds whilst also identifying new components and new commercial opportunities.