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of the patient is multifactorial, with genetic, biochemical profile immune system and lifestyle as a protagonist of such a process which has as one of the clinical outcomes hepatic fibrosis, increasing the progression of the cell subject to hepatocellular carcinoma. These parameters directly influence the fibrous framework of HCV patients that may be worsened by maintaining physical inactivity frame and biochemical profile disruption, since it favors the inflammatory and fibrogenic process. Since studies with patients with HCV and physical activity are quite scarce, they demonstrate the efficacy of physical activity on the fibrotic and hepatic condition of patients with hepatitis C virus, since this requires a prescriptive planning with quality and adequate for these individuals. Thus defining the best type of physical activity or exercise that will bring the best effects to patients with hepatitis C and other hepatic comorbidities, which can condition the lifestyle of these individuals and thus lead to better pathophysiological stages, avoiding the progression of the disease, providing an improvement of their health, and psychosocial since the physical activity and / or exercise guarantee the activation of elements linked to the neuroendocrine axis activating the secretion of endorphins guaranteeing the well-being of the patients with this pathology. Thus the objective of this review is to describe the main benefits of physical activity within the pathophysiological processes found in patients with HCV.

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Maternal nutrition affects offspring physiology and behavior including susceptibility to mental health‐related states. Perinatal high‐fat diet (HFD) consumption has been associated with lower levels of serotonin as well as the development of anxiety‐like and depression‐like behaviors in offspring. The aim of this systematic review was to investigate the effects of maternal HFD during pregnancy and/or lactation on these behaviors and on some aspects of the serotonergic system. Criteria for eligibility included studies of offspring of rodents and non‐human primates exposed to HFD at least during pregnancy and/or lactation, offspring that showed outcomes related to anxiety‐like and depression‐like behaviors and to the serotonergic system. The searches were realized in the LILACS, Web of Science, Scopus, and PubMed databases. The systematic review protocol was registered on the CAMARADES website. The internal validity was assessed by the SYRCLE risk of bias tool. The Kappa index was used for analyzing agreement among the reviewers. In addition, the PRISMA statement was used to report this systematic review. Sixteen articles were included in this review. Most of which studied HFD prior to mating and during pregnancy and lactation. All studies analyzed outcomes related to emotional behavior; three analyzed outcomes related to serotonin system compounds. Maternal consumption of HFD was found to be associated with an inconsistent pattern of the expression of TPH2 as well as reduced the immunoreactivity of 5‐HT in the prefrontal cortex and increased 5‐HT1A receptor expression in the dorsal raphe of offspring. An association between an HFD and alterations in emotional behavior was found in most of the studies selected.