Until today, the mechanism of action of drugs is traditionally considered without taking into account the physical-chemical properties of dosage forms. However, at the beginning of the 21st century, there were reports that all drugs contain unaccounted gases that enter drugs from the air and affect the quality of drugs. It is shown that the composition and amount of gases in the dosage forms of all drugs changes their mechanical, physical, chemical and physical-chemical properties and the mechanism of action of drugs, especially when applied topically It is reported that changing the content of gases in drug solutions and tablets allows to regulate their mass, volume, specific gravity, porosity, physico-chemical activity and local action on the routes of drug administration. The identification of this pattern allowed to start the production of completely new drugs with a certain gas composition and with a new local pharmacokinetics and a new local pharmacodynamics. The formulations of new drugs in which gas is an auxiliary, formative or main ingredient are given. It is proposed to control the gas composition of medicines as an indicator of their quality and an important factor of their physical-chemical activity. It is proved that the gas in the drug can be not only neutral, but also auxiliary, oppositional, and sometimes the main ingredient. Thus, the control and accounting of the gas contained in drugs will allow the creation of a new generation of drugs in the near future.

Pyolytics are drugs that dissolve thick pus when applied topically. This group of drugs was discovered in early 21st century in Russia as a result of successful repurposing of antiseptics hydrogen peroxide, sodium bicarbonate and sodium chloride from antiseptics to pyolytics. Prior to this watershed event in pharmacy, the problem of effective treatment of purulent diseases had not been solved. The fact is that before that in the treatment of various purulent diseases mainly antiseptics and disinfectants solutions were used, of which hypertonic sodium chloride solution and 3 - 6% hydrogen peroxide solutions took the leading role as "antipurulent" drugs. However, the use of the known antiseptics and disinfectants solutions provided disinfection of the treated surface, but not dissolution of thick pus masses, as the solutions had no effective pyolytic action. Pyolytic activity, i.e. activity of dissolution of thick pus masses, was fantastically increased in hydrogen peroxide solutions only after the possibility of transformation of "old" drugs into "new" drugs by means of artificial changes in physical and chemical properties of their dosage forms was discovered. The greatest (explosive) effect was achieved by developing warm alkaline hydrogen peroxide solutions enriched with oxygen gas under increased pressure. In chronological order, an overview is given of Russian inventions, which formed the basis for the physicochemical repurposing of hydrogen peroxide solutions into pyolytics as well as the basis of temperature and physicochemical pharmacology and pharmaceutics.

Coronavirus infection influences on multiple organs and contributes to the progression of concurrent diseases. The most notable and outstanding changes and COVID complications appear in patients with pre – existing cardiovascular and metabolic disturbances especially in elderly. There is evidence that acute viral as well as chronical diseases promote rapid cell senescence and prolong the process of recovery from disease. This review reflects the main common points and axis joining the pre-existing diseases and coronavirus infections complications and resolution. Diabetes mellitus type 2 and cardiovascular diseases (hypertension) predispose to severe outcome of the disease and the COVID-19 mortality risk. The Klotho protein level may be promising predictor of COVID severity and complications in many patients. In order to control properly the rehabilitation process and estimate the level of treatment efficacy we tried to reflect the property of milestone clue biomarker of senescence and cell damage – Klotho protein.