No abstract

Machine learning (ML) methods are becoming ever more prevalent across all domains of lifesciences. However, a key component of effective ML is the availability of large datasets thatare diverse and representative. In the context of health systems, with significant heterogeneityof clinical phenotypes and diversity of healthcare systems, there exists a necessity to developand refine unbiased and fair ML models. Synthetic data are increasingly being used to protectthe patient’s right to privacy and overcome the paucity of annotated open-access medical data. Here, we present our proof of concept for the generation of synthetic health data and our proposed FAIR implementation of the generated synthetic datasets. The work was developed during and after the one-week-long BioHackathon Europe, by together 20 participants (10 new to the project), from different countries (NL, ES, LU, UK, GR, FL, DE, . . . ).

The success of carsharing as a relatively new and more sustainable way of traveling is moving private car ownership towards a service use model. Competitivity is an essential aspect of this service and ways to increase profit while offering the most appealing service are still getting explored. Among others, dynamic pricing strategies can be designed to increase profit by attracting more users, selling more rental hours, or maximizing fleet utilization. In this paper, we propose an experimental method aimed at developing a model for maximizing service profit. Using agent-based modeling to generate realistic scenarios, we analyze pricing as a function of the potential demand (i.e., number of members) and supply (hours of booking supplied). The process of reaching the maximum profit consists of testing various combinations of pricing-demand and pricing-supply ranges in order to find the values that maximize the profit for every demand and supply level. Once the optimal prices are known, a polynomial fitting and an optimization method are used to generate a functional form linking all the maximal profit obtaining the advised price to offer for any specific supply levels. Results show how the profit only slightly depends on the variability of the potential demand, while it strongly depends on the amount of supply. It is then shown how it is possible to obtain a linear relation that maximizes the profit in the function of the price offered once the supply is given.