Leadership is a topic of great conceptual approach and is considered fundamental in the work process of healthcare organizations as well as knowledge management. This study carried out a literature review to identify the leadership in the health domain with regard to knowledge management in health organizations in articles published in the last 05 years. The data search was performed in PubMed/Medline, Scielo, and Scopus, using the descriptors: leader*; health; knowledge management, which resulted in 136 articles. Of these, 22 were selected in the first analysis, of which 8 were chosen to support this study, which applied the method of integrative literature review. The research findings indicate that leadership and the role of leaders have strong contributions to the knowledge management process in healthcare organizations.