The yeast Saccharomyces cerevisiae, a microorganism with cell walls resistant to many types of treatments, was chosen as a model to study electrochemical disinfection process using dimensionally stable anodes (DSA). DSA electrodes with nominal composition of Ti/RuOTiO and Ti/RuOTiOIrO were evaluated in 0.05 mol L NaSO containing yeast. The results showed inactivation about of 100 % of the microorganisms at Ti/RuOTiO by applying 20 and 60 mA cm after 120 min of electrolysis, while a complete inactivation at Ti/RuOIrOTiO electrode was achieved after 180 min at 60 mA cm. When chloride ions were added in the electrolyte solution, 100 % of the yeast was inactivated at 20 mA cm after 120 min of electrolysis, independent of the anode used. In the absence of chloride, the energy consumption (EC) was of 34.80 kWh m, at 20 mA cm by using Ti/RuOTiO anode. Meanwhile, in the presence of chloride, EC was reduced, requiring 30.24 and 30.99 kWh m at 20 mA cm, for Ti/RuOTiO and Ti/RuOIrOTiO electrodes, respectively, The best performance for cell lysis was obtained in the presence of chloride with EC of 88.80 kWh m (Ti/RuOTiO) and 91.85 kWh m (Ti/RuOIrOTiO) to remove, respectively, 92 and 95 % of density yeast. The results clearly showed that yeast, as a model adopted, was efficiently inactivated and lysed by electrolysis disinfection using DSA-type electrodes.