Our overview shows that LI is associated with a lower risk of construction of the stoma outcome measures.

Although the optimal treatment of gynecological PEComas is controversial, surgical resection remains the cornerstone. The use of adjuvant treatment is warranted in high risk patients to increase disease control. A multidisciplinary approach should be key in treatment decision-making regarding gynecological PEComas.

No abstract

Background-Estrogens may induce the proliferation of neoplastic cells by activating neoangiogenesis.Aim-To evaluate the effect of estrogens on the expression of vascular endothelial growth factor (VEGF) and related receptors (VEGF-R) in human cholangiocarcinoma and the role played by VEGF in mediating the proliferative effects of estrogens.Methods-Seven biopsies of intra-hepatic cholangiocarcinoma and the HuH-28 cell lines were investigated. Cell proliferation was measured by both PCNA Western blot and MTS proliferation assay.Results-By immunohistochemistry, biopsies of human cholangiocarcinoma stained positively for VEGF-A and VEGF-C and related receptors. HuH-28 cells expressed VEGF-A, -C, and VEGFR-1, -2, -3 and, their protein level was enhanced by 17β-estradiol in association with the stimulation of cell proliferation. 17β-Estradiol-stimulated proliferationof HuH-28 cells was blocked by 70% by VEGF-trap, a receptor-based VEGF inhibitor. 17β-Estradiol induced the secretion of VEGF in the