This study aims to determine effect of work environment and work stress on the performance of nurses at RSU Kertha Usada amid the COVID-19 pandemic. By examining three variables, namely work environment and work stress as independent variables and performance as dependent variables. This study involved 107 samples of permanent nurses at RSU Kertha Usada. Data were collected using a questionnaire method and analyzed using path analysis. The results showed that (1) work environment and work stress have a significant effect on performance by 24.1%. (2) The work environment has a positive and significant effect on performance by 36.3%. (3) Job stress has a negative and significant effect on performance by 22.9%. (4) The work environment negatively and significantly affects work stress by 34.0%.