ObjectivesVariable ventilation (VV) seems to improve respiratory function in acute lung injury and may be combined with positive end-expiratory pressure (PEEP) in order to protect the lungs even in healthy subjects. We hypothesized that VV in combination with moderate levels of PEEP reduce the deterioration of pulmonary function related to general anesthesia. Hence, we aimed at evaluating the alveolar stability and lung protection of the combination of VV at different PEEP levels.DesignRandomized experimental study.SettingAnimal research facility.SubjectsForty-nine male Wistar rats (200–270 g).InterventionsAnimals were ventilated during 2 hours with protective low tidal volume (VT) in volume control ventilation (VCV) or VV and PEEP adjusted at the level of minimum respiratory system elastance (Ers), obtained during a decremental PEEP trial subsequent to a recruitment maneuver, and 2 cmH2O above or below of this level.Measurements and Main ResultsErs, gas exchange and hemodynamic variables were measured. Cytokines were determined in lung homogenate and plasma samples and left lung was used for histologic analysis and diffuse alveolar damage scoring. A progressive time-dependent increase in Ers was observed independent on ventilatory mode or PEEP level. Despite of that, the rate of increase of Ers and lung tissue IL-1 beta concentration were significantly lower in VV than in VCV at the level of the PEEP of minimum Ers. A significant increase in lung tissue cytokines (IL-6, IL-1 beta, CINC-1 and TNF-alpha) as well as a ventral to dorsal and cranial to caudal reduction in aeration was observed in all ventilated rats with no significant differences among groups.ConclusionsVV combined with PEEP adjusted at the level of the PEEP of minimal Ers seemed to better prevent anesthesia-induced atelectasis and might improve lung protection throughout general anesthesia.

O presente trabalho apresenta uma revisão crítica dos critérios diagnósticos e modelos de determinação da anorexia e bulimia, a partir de publicações veiculadas no International Journal of Eating Disorders. Questiona, particularmente, a noção de determinação interna destes transtornos, enfatizando a questão da fobia de peso (fat phobia) como um exemplo deste modo de interpretação. A recuperação do modelo biocomportamental de anorexia induzida por atividade física (activicty anorexia), e do conjunto de experimentos que o embasam, pretende incitar a consideração de explicações alternativas aos transtornos alimentares, sem a necessidade de apelo para variáveis cognitivas ou emocionais como determinantes destes transtornos.

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