Keefe et althat can be referenced by primary care providers, as well as general and pediatric urologists, in order to help standardize the care of pediatric urology patients during the pandemic and provide guidance on managing the surge of patients once restrictions begin to be lifted.

Neural network quantization and pruning are two techniques commonly used to reduce the computational complexity and memory footprint of these models for deployment. However, most existing pruning strategies operate on full-precision and cannot be directly applied to discrete parameter distributions after quantization. In contrast, we study a combination of these two techniques to achieve further network compression. In particular, we propose an effective pruning strategy for selecting redundant low-precision filters. Furthermore, we leverage Bayesian optimization to efficiently determine the pruning ratio for each layer. We conduct extensive experiments on CIFAR-10 and ImageNet with various architectures and precisions. In particular, for ResNet-18 on ImageNet, we prune 26.12% of the model size with Binarized Neural Network quantization, achieving a top-1 classification accuracy of 47.32% in a model of 2.47 MB and 59.30% with a 2-bit DoReFa-Net in 4.36 MB.

Background Access to prevention options, including HIV pre-exposure prophylaxis (PrEP), remains a public health priority for gay, bisexual, and other men who have sex with men (MSM), especially in London. We describe PrEP use in a London community sample of MSM before the introduction of a national PrEP programme in October 2020. Methods From June–August 2019, MSM aged ≥ 18 recruited from London commercial venues were asked to self-complete a sexual health questionnaire and provide an oral fluid sample for anonymous HIV antibody testing. Descriptive analyses of demographic characteristics, service engagement and outcomes, as well as sexual risk and prevention behaviours were examined in the survey population and in those reporting current PrEP use. We performed sequential, multivariate analyses examining current PrEP use in MSM of self-perceived HIV-negative/unknown status with identified PrEP-need defined as the report of condomless anal sex (CAS) in the last three months, or the report of CAS (in the last year) with an HIV-positive/unknown status partner not known to be on HIV treatment, in reflection of UK PrEP guidelines. Results One thousand five hundred and thirty-fifth questionnaires were completed across 34 venues, where 1408 were analysed. One in five MSM of self-perceived HIV-negative/unknown status reported current PrEP use (19.7%, 242/1230). In men with PrEP-need, 68.2% (431/632) did not report current use. Current PrEP use was associated with age (aOR: 3.52, 95% CI: 1.76–7.02 in men aged 40–44 vs men aged 18–25) and education (aOR: 1.72, 95% CI: 1.01–2.92 in men with ≥ 2 years/still full-time vs no/ < 2 years of education since age 16). Conclusion Among MSM in London, PrEP use is high but there is indication of unmet PrEP-need in men of younger age and lower levels of post-16 education. National programme monitoring and evaluation will require continued community monitoring to guide interventions ensuring equitable PrEP access and uptake in those who could most benefit from PrEP.

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