While feasible, this regimen showed heavy toxicity. Nevertheless, 74% of the patients were able to complete the planned treatment. Adjustment of the schedule of IFO continuous infusion to improve this combination is currently under investigation.

Abstract.-This study analyses the seasonal fisheries and sexual proportion of the narrownose smooth-hound Mustelus schmitti from the Uruguayan oceanic coast. The maximum catches took place during the fall. Of a total of 2105 individuals, 1483 were males and 622 females, being females larger than males. Females were dominant at maximum depths of 50 m (inner shelf), whereas males occupied major depths of 50 m (outer shelf). The great proportion of mature females on the inner shelf during spring and summer, and mature males in summer are related to the mating, ovulation and delivery time as previously proposed for this shark in this area. The length in which 50% of the females were retained was below or on the length of sexual maturity of the narrownose smooth-hound, indicating that these are more affected by the fishing activity. Nevertheless, an important fraction of the population that distributes on the inner and outer shelf during the time of parturition, ovulation and mating would be protected in spring and summer by the establishment of fishing bans of the fishes Cynoscion guatucupa and Merluccius hubbsi.

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In this work we analyzed the spatial and seasonal variation of length distribution, sexual proportion and mature dominance for Atlantoraja cyclophora and A. castelnaui, at the Uruguayan continental shelf. There were significant differences in total length (TL) composition between sexes, being females bigger than males for both species. Atlantoraja cyclophora showed a relatively uniform length distribution between inner and outer shelf. There were no major variations in the sex compositions and in the mature dominance between seasons, suggesting no temporal variation. Atlantoraja castelnaui showed a significant variation in its spatial and seasonal distribution. Individuals were smaller in inner shelf, pointing out the existence of juvenile zone in areas up to 50 m depth. A tendency to capture smaller individuals towards the end of the year was observed. In all seasons over 50% of females were caught below the estimated size at maturity, suggesting that this species is highly susceptible to exploitation. R E S U M ONeste trabalho foi analisada a variação espacial e temporal da distribuição de comprimento, proporções sexuais e dominância de maduros para Atlantoraja cyclophora e A. castelanui, na plataforma continental uruguaia. Houve diferenças significativas na distribução do comprimento total (TL) entre os sexos, sendo as fêmeas maiores que os machos para ambas espécies. Atlantoraja cyclophora mostrou uma distribuição relativamente uniforme de comprimento entre a prataforma interna e externa. Não houviram grandes variações nas composições do sexo e na dominância de maduros entre as estações do ano, sugerindo que não ha variação temporal. Atlantoraja castelnaui mostrou uma variação significativa na sua distribuição espacial e sazonal. Os indivíduos foram menores na plataforma interna, apontando para a existência de uma zona de juvenis em áreas de até 50 m de profundidade. A tendência para a captura de indivíduos menores no final do ano foi observada. Em todas as estações do ano mais de 50% das fêmeas foram capturadas em um comprimento menor ao tamanho estimado de maturidade observado na literatura, sugerindo que esta espécie é altamente suscetível à explotação.