BackgroundGenitourinary tuberculosis is the third most common form of extrapulmonary tuberculosis. Diagnosis is difficult because of unspecific clinical manifestations and low accuracy of conventional tests. Unfortunately, the delayed diagnosis impacts the urinary tract severely. Nucleic acid amplification tests yield fast results, and among these, new technologies can also detect drug resistance. There is lack of consensus regarding the use of these tests in genitourinary tuberculosis; we therefore aimed to assess the accuracy of nucleic acid amplification tests in the diagnosis of genitourinary tuberculosis and to evaluate the heterogeneity between studies.MethodsWe did a systematic review and meta-analysis of research articles comparing the accuracy of a reference standard and a nucleic acid amplification test for diagnosis of urinary tract tuberculosis. We searched Medline, EMBASE, Web of Science, LILACS, Cochrane Library, and Scopus for articles published between Jan 1, 1990, and Apr 14, 2016. Two investigators identified eligible articles and extracted data for individual study sites. We analyzed data in groups with the same index test. Then, we generated pooled summary estimates (95% CIs) for sensitivity and specificity by use of random-effects meta-analysis when studies were not heterogeneous.ResultsWe identified eleven relevant studies from ten articles, giving information on PCR, LCR and Xpert MTB/RIF tests. All PCR studies were “in-house” tests, with different gene targets and had several quality concerns therefore we did not proceed with a pooled analysis. Only one study used LCR. Xpert studies were of good quality and not heterogeneous, pooled sensitivity was 0·87 (0·66–0·96) and specificity was 0·91 (0·84–0·95).ConclusionPCR studies were highly heterogeneous. Among Xpert MTB/RIF studies, specificity was favorable with an acceptable confidence interval, however new studies can update meta-analysis and get more precise estimates. Further high-quality studies are urgently needed to improve diagnosis of genitourinary tuberculosis.Protocol registrationPROSPERO CRD42016039020.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2476-8) contains supplementary material, which is available to authorized users.

Patients with BPH that present moderate LUTS did not show any benefit receiving BO when compared to placebo.

The cross-culturally validated IIEF in Peru is a valid and reliable instrument for its local use in the fields of clinics and research.

To the editor:We read with interest the article by Kulchavenya and Kholtobin on urogenital tuberculosis (UGTB) [Kulchavenya and Kholtobin, 2015], in which the authors provide information about unusual UGTB cases. While the authors claim that they have carried out a systematic review of the topic, we completely disagree with that statement. Systematic reviews represent the highest level of evidence available for making clinical decisions, particularly if they are based on high quality studies and a strict and accurate methodology has been followed [Akobeng, 2005].A comprehensive and exhaustive search for primary studies that attempt to answer a clinical question is a key starting point to every systematic review; in the manuscript it is not clear what the authors want to answer. The title points towards diseases that mimic and delay diagnosis of UGTB, but the authors instead reviewed uncommon presentations of UGTB with no focus at all on diagnosis delay. Second, the search strategy included reviewing only the PubMed database, which has been considered an insufficient strategy for performing a literature search [SuarezAlmazor et al. 2000]. Other databases such as Embase should have been incorporated. In addition, most of the studies included were case reports, and guidelines for reviewing cases reports such as the CARE guidelines and the Institute of Health Economics tool for case series were not followed [Gagnier et al. 2013;Moga et al. 2012]. Third, no clear information on the selection criteria is provided; it is not clear what was considered a usual or a rare case of UGTB. Finally, the results were presented as a narrative review with no clear outcomes of their investigation.Considering that UGTB is a difficult entity to diagnose, the review of unusual UGTB presentations can be a first step to fill the lack of evidence on the topic. We suggest the authors should use the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines [Moher et al. 2009]. These guidelines stand for high quality systematic reviews ensuring a transparent and thorough report of data. Authors' endorsement of this kind of checklists warrants excellence in research and evidence-based medicine. FundingThis research received no specific grant from any funding agency in the public, commercial, or notfor-profit sectors. Conflict of interest statementThe authors declare no conflicts of interest in preparing this article.

La presente investigación comprende el estudio de dos variables, la cual lleva por título E-Commerce y su relación con la Satisfacción del Cliente de la Empresa V&C Motor's E.I.R.L - Chincha – 2022. Se tuvo como objetivo principal determinar la relación que existe entre el e-commerce y la satisfacción del cliente en dicha empresa. Para la investigación se planteó una metodología básica con un enfoque cuantitativo, tuvo un nivel correlacional y de diseño no experimental – transversal. Para la recolección de datos se recurrió a la encuesta, donde se aplicó como instrumento un cuestionario de elaboración propia, conformado por 24 preguntas. Así mismo para el estudio se tuvo una población de 130 clientes, estableciéndose una muestra de 97 clientes pertenecientes a la empresa V&C Motor´s. Por lo tanto, de acuerdo al análisis realizado, el Rho de Spearman tuvo un coeficiente de correlación de 0,776, con lo cual se concluyó que si existe una relación positiva alta entre ambas variables de estudio. Además, el nivel de significancia fue de 0,000, donde se rechazó todas las hipótesis nulas y se aceptaron las hipótesis alternativas, demostrando así que también existe relación entre las variables y dimensiones en estudio.