To establish the profile of patients who developed antiangiogenic agent-related osteonecrosis of the jaws, and identify the treatments currently used in dental management. We searched the PubMed ® /Medline ® and Scopus databases using the words “osteonecrosis AND antiangiogenic therapy”, with the following inclusion criteria: articles published in English, case reports, available online, and for an unlimited period. Of the 209 articles retrieved, 18 were selected, for a total of 19 case reports, since one article included two cases that met the inclusion criteria for this study. Medication-related osteonecrosis of the jaws is characterized by exposure of necrotic bone in the oral cavity that does not heal over a period of 8 weeks in patients with no previous history of radiation therapy. Antiangiogenic drugs are indicated in the treatment of certain tumors, since they stop the formation of new blood vessels, controlling tumor growth and the chance of metastasis. Dental prevention is essential in patients who will be put on antiangiogenic agents, to minimize the risk for osteonecrosis.

A terapia antineoplásica gera imunossupressão e alterações na cavidade bucal que muitas vezes pioram o quadro geral dos pacientes, podendo culminar na interrupção do tratamento quimioterápico, no entanto os cuidados bucais podem diminuir a morbidade e mortalidade dos pacientes oncológicos. Diante disso, esta revisão de literatura tem como objetivo apresentar uma sugestão de cuidados odontológicos para as manifestações bucais que podem ocorrer antes, durante e depois do tratamento antineoplásico em crianças com leucemias. A busca na literatura foi realizada por meio da base de dados Pubmed, Lilacs e Bibliografia Brasileira de Odontologia (BBO), além de capítulos de livros, dissertações. Diante disso, esta revisão mostrou as alterações bucais mais frequentes nas fases das leucemias e propôs algumas formas de tratamento odontológico para o suporte a estes indivíduos, os quais receberam terapia antineoplásica, com o objetivo de proporcionar aos profissionais da saúde opções terapêuticas que melhorem a qualidade de vida dos indivíduos com leucemias. Palavras-chave: Leucemia, Manifestações Orais, Assistência odontológica para crianças, Antineoplásicos.

Bernard-Soulier syndrome (BSS) is an inherited bleeding disorder characterized by macroplatelets and thrombocytopenia, prolonged bleeding time, and a prevalence of less than 1 in 1,000,000. In view of the recognition of the risk of bleeding and the management of daily surgical practice in these patients, adequate strategies are necessary to provide the safest care. This article aims to perform an integrative review of the literature on the management of invasive procedures in the oral cavity of individuals with BSS. Method: The PubMed/Medline and LILACS databases were searched using Boolean operators related to BSS, bleeding disorders, and oral care. Results: As a result, only five articles with the main theme were included: one letter to the editor and four case reports, described chronologically as to date of publication, classification of the article, and medical/odontological measures taken. Conclusion:We conclude with this review the need for adequate knowledge of surgeons regarding coagulation disorders and the need to discuss and plan procedures with the hematology team, as well as the importance of the notion of management of possible complications resulting from invasive treatments in the oral cavity of patients with BSS.

Cirurgiões-dentistas habilitados em práticas baseadas em evidências científicas e na aplicação de modelos de cuidados em saúde bucal bem-sucedidos trazem benefícios tanto à saúde individual quanto à coletiva. Este estudo traçou um panorama sobre cursos de Habilitação em Odontologia Hospitalar ofertados no Brasil após a regulamentação da Resolução 162/2015 pelo Conselho Federal de Odontologia (CFO), para auxiliar a escolha dos profissionais que pretendem se habilitar na área. O método de pesquisa foi a revisão integrativa da literatura, com análise quantitativa, exploratória e descritiva dos dados. O modelo de busca aplicado foi “habilitação em odontologia hospitalar”, na base de dados Google, com uma única consulta em março de 2019. Dezessete (17) propostas foram encontradas. Seguiram para análise treze (13) propostas que informavam número de vagas ofertadas, periodicidade do curso, dias da semana em que ocorriam as atividades, carga horária total, conteúdo programático (teórico e prático) e local da prática. Falta de conteúdo programático (n=2) e de atualização (n=1) foram critérios de exclusão imediata. Na análise descritiva das propostas (n=10) houve exclusões por falta de definição da carga horária teórica e prática (n=4); informação sobre o conteúdo prático (n=5) e de identificação do local de desenvolvimento e carga horária mínima exigida para a prática. O estudo evidenciou que, à época da coleta de dados, apenas uma proposta atendia à legislação e à normativa exigidas pelo CFO.

<p lang="pt-PT"><span style="color: #000000;"><span style="font-family: Cambria, serif;"><span><span style="font-family: Arial, serif;"><span lang="en-US"><strong>Objective</strong></span></span><span style="font-family: Arial, serif;"><span lang="en-US">: The aim of this paper is to update the current published content about the craniofacial long-term development disturbances of childhood hematopoietic stem-cell transplantation (HSCT) and the preparative regimens for the onco-hematological malignancies treatments. <strong>Material and </strong></span></span><span style="font-family: Arial, serif;"><span lang="en-US"><strong>Methods</strong></span></span><span style="font-family: Arial, serif;"><span lang="en-US">: Two authors independently reviewed the published articles about long-term effects of childhood HSCT that fitted in to predetermined inclusion/exclusion criteria: clear definition of exposure or intervention, standard outcomes measurement and appropriate statistical analysis. </span></span><span style="font-family: Arial, serif;"><span lang="en-US"><strong>Results</strong></span></span><span style="font-family: Arial, serif;"><span lang="en-US">: </span></span><span style="font-family: Arial, serif;"><span lang="en-GB">Twelve papers matched all the previous established eligibility criteria and were included in this review. </span></span><span style="font-family: Arial, serif;"><span lang="en-US">The children’s age at HSCT were related to a higher risk of dental development disturbances, such as agenesis, dental hypoplasia, root stunting, crown-root proportion alterations, and microdontia. Craniofacial vertical growth was impaired in the irradiated patients without antero-posterior or latero-lateral impairment. Temporomandibular joint dysfunction was found to be more prevalent in the patients who was diagnosed with graft-versus-host disease. </span></span><span style="font-family: Arial, serif;"><span lang="en-US"><strong>Conclusion</strong></span></span><span style="font-family: Arial, serif;"><span lang="en-US">: The late effects of craniofacial development disturbances leads to several aesthetic and functional impairment, periodontal bone resorption with consequent impairment of chewing ability, and risk of early tooth loss often associated with life’s quality impairment. Further investigations should be performed to provide accurate information for patients, parents and health care professionals. </span></span></span></span></span></p><p lang="en-US"><span style="color: #345a8a;"><span style="font-family: Calibri, serif;"><span><span style="color: #00000a;"><span style="font-family: Arial, serif;"><span><strong>Keywords</strong>: Dental development. Craniofacial growth. Bone marrow transplantation. Hematopoietic stem-cell transplantation. </span></span></span><span style="color: #00000a;"><span style="font-family: Arial, serif;"><span><span lang="pt-BR">Chemotherapy. Radiotherapy.</span></span></span></span></span></span></span></p>