The objective of this work was to characterize the properties of a synthetic biomaterial composite with nanoparticles size (Blue Bone). This biomaterial is a composite recommended for dental and orthopedic grafting surgery, for guided bone regeneration, including maxillary sinus lift, fresh alveolus filling, and treatment of furcation lesions. The nano biomaterials surface area is from 30% to 50% higher than those with micro dimensions. Another advantage is that the alloplastic biomaterial has homogeneous properties due to the complete manufacturing control. The analyzed biomaterial composite was characterized by XRD, cytochemistry, scanning electron microscopy, porosimetry and in vivo experiments (animals). The results showed that the analyzed biomaterial composite has 78.76% hydroxyapatite [Ca5(PO4)3(OH)] with monoclinic structure, 21.03% β-tricalcium phosphate [β -Ca3(PO4)2] with trigonal structure and 0.19% of CaO with cubic structure, nanoparticles with homogeneous shapes, and nanoporosity. The in vivo experiments showed that the composite has null cytotoxicity, and the site of insertion biomaterials has a high level of vascularization and bone formation. The conclusion is that the synthetic biomaterial with Blue Bone designation presents characteristics suitable for use in grafting surgery applications.

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Significance and Impact of the Study: The occurrence and severity of fungal infections have increased in recent decades due to resistance to available antifungal drugs and the appearance of new emerging pathogens. Thus, the search for new antifungal agents is mandatory. From a series of 23 cinnamyl Schiff bases, two compounds (1 and 23) were interrogated as new anticryptococcal agents without significant cytotoxicity against human lung, kidney or red blood cells. In turns, these new Schiff bases are lead compounds for the discovery of novel antifungal drugs.

The Cr-Co-Mo alloys are commonly used in dentistry for prosthetic components and dental implant supported prosthesis. These alloys present high corrosion resistance owing to a passive oxide film on the surface. However, the oral environment is an aggressive system, due to pH variation, chloride and fluoride ions presence, that can decrease the metal alloy corrosion resistance. Although Cr-Co-Mo alloys have been used for a long time, their electrochemical properties on different pH have not been studied yet. This study aimed to evaluate the electrochemical properties of Cr-Co-Mo alloy in NaCl 0.9% solution in different pH and mouthwash solution. To imitate the oral environment, electrolytes with a pH equal to 2, 3, and 6 were used. Corrosion studies were performed by open circuit potential observation, potentiodynamic polarization curve, chronoamperometry and electrochemical impedance. The results showed that the analyzed alloy has good corrosion resistance under experimental conditions, although the acidified NaCl 0.9% solution increased the corrosion current, particularly in cathodic potentials.

Bone loss is common in human old age and new materials that promote bone regeneration are an active line of research. In the present work, seven smart hydrogels based on PNIPAAm were synthesized with the prospective to be used in tissue engineering as a scaffold for bone growth. By changing the stoichiometric concentrations of the reagents and the synthesis parameters, hydrogels with different physical properties and morphology were obtained. Swelling, degradation properties, and crystallinity were analyzed. Physical properties were characterized using 1H-NMR, FTIR, and TGA. The results showed that the swelling degree (degree of mass expansion) varied at room temperature from 1,400% for less rigid hydrogels to 550% for stiffer hydrogels. With heating to body temperature, swelling decreases to 300% and 200%, respectively. The samples presented three-dimensional morphology, but they acquired different structures according to the magnetic stirring during the synthesis process. The crosslink and initiator concentrations have an important effect on the polymeric structure and thermal stability of the hydrogels. The PNIPAAm synthesized using 8.9 and 15.7 mol % of MBA are the most promising compounds to be used in the future as a scaffold for biomedical applications due to their high thermal stability, satisfactory 3D surface morphology, and shrinking-swelling property.