There are numerous over-the-counter (OTC) and professionally applied (in-office) products and techniques currently available for the treatment of dentine hypersensitivity (DH), but more recently, the use of bioactive glasses in toothpaste formulations have been advocated as a possible solution to managing DH. Aim. The aim of the present study, therefore, was to compare several bioactive glass formulations to investigate their effectiveness in an established in vitro model. Materials and Methods. A 45S5 glass was synthesized in the laboratory together with several other glass formulations: (1) a mixed glass (fluoride and chloride), (2) BioMinF, (3) a chloride glass, and (4) an amorphous chloride glass. The glass powders were formulated into five different toothpaste formulations. Dentine discs were sectioned from extracted human teeth and prepared for the investigation by removing the cutting debris (smear layer) following sectioning using a 6% citric acid solution for 2 minutes. Each disc was halved to provide test and control halves for comparison following the brushing of the five toothpaste formulations onto the test halves for each toothpaste group. Following the toothpaste application, the test discs were immersed in either artificial saliva or exposed to an acid challenge. Results. The dentine samples were analyzed using scanning electron microscopy (SEM), and observation of the SEM images indicated that there was good surface coverage following artificial saliva immersion. Furthermore, although the acid challenge removed the hydroxyapatite layer on the dentine surface for most of the samples, except for the amorphous chloride glass, there was evidence of tubular occlusion in the dentine tubules. Conclusions. The conclusions from the study would suggest that the inclusion of bioactive glass into a toothpaste formulation may be an effective approach to treat DH.
Objetivo: analisar informações significativas disponíveis na literatura sobre DH e suas opções de tratamento com foco no papel dos cremes dentais bioativos à base de vidro. Material e Métodos: foi realizada uma pesquisa bibliográfica em bases de dados eletrônicas, incluindo PUBMed e Scielo, utilizando as palavras-chave: (Dentifrício OU Dentifrícios) OU (Creme Dental OU Cremes) E (Tratamento) E (Dentina OU Dentina OU Dente) E (Hipersensibilidade OU Sensibilidade) E (Dentifrício OU Dentifrícios) E (Tratamento OU Tratamentos) E (Dentinária OU Dentina OU Dente) E (Hipersensibilidade OU Sensibilidade). Os artigos encontrados foram analisados em relação ao conteúdo do título e resumo, a fim de eliminar aqueles que estavam fora do contexto e não eram relevantes para a revisão. Resultados: após este primeiro filtro, 31 artigos foram selecionados, em que o texto completo disponível foi considerado de boa qualidade e relevante para o contexto. As línguas dos jornais eram predominantemente inglesas e Português e artigos publicados antes de 2002 foram excluídos. O uso de óculos bioativos em formulações de dentifrícios tem sido defendido como uma possível solução para gerenciamento de DH. Conclusão: existem várias opções diferentes para o tratamento da DH, embora os dentifrícios contendo vidro bioativo sejam uma opção promissora.
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