Background: Physical exercise is one of the essential activities people can do to improve their health and is a necessary asset for healthy aging. However, over-exercising may lead to an increase in the range of acute and overuse musculoskeletal injuries. The aim of this study was to estimate the extent of exercise-related injuries and evaluate the common types of those injuries among female gym members in the Qassim region. Methodology: In this prevalence study, we targeted women attending gym centers in the Qasism region. A structured questionnaire was delivered online and 247 respondents completed the questionnaire. The main outcome measured were self-reported injuries, their location, and type. Results: Of the respondents, 49% of them responded yes, they have injuries and, on the other hand, 51% had no injuries. There was no difference in the frequency of injuries between members who were trained by a trainer and those who are not (p-value = 0.788). Injuries varied according to body mass index (BMI). Injuries by anatomic location were counted as: injuries of the ankle (20.9%), the second most common location was the knee (19.0%), and the third most common location was the thigh (15.7%). The most common injury by body part was the injury of the muscles (55.7%) and most of these injuries were muscle strains (52.2%). Other less common injuries included ankle sprains and traumas that led to different bruises. Conclusion: Physical activity is an important component in improving and maintaining health; however, injury is also an accompanying risk, and since the physical exercise trend is increasing among females in Saudi Arabia, we need more effective injury prevention methods.

Background: Cancer is the leading cause of death worldwide with breast and prostate cancer the most common among women and men, respectively. Gene expression and image features are independently prognostic of patient survival; but until the advent of spatial transcriptomics (ST), it was not possible to determine how gene expression of cells was tied to their spatial relationships (i.e., topology). Methods: We identify topology-associated genes (TAGs) that correlate with 700 image topological features (ITFs) in breast and prostate cancer ST samples. Genes and image topological features are independently clustered and correlated with each other. Themes among genes correlated with ITFs are investigated by functional enrichment analysis. Results: Overall, topology-associated genes (TAG) corresponding to extracellular matrix (ECM) and Collagen Type I Trimer gene ontology terms are common to both prostate and breast cancer. In breast cancer specifically, we identify the ZAG-PIP Complex as a TAG. In prostate cancer, we identify distinct TAGs that are enriched for GI dysmotility and the IgA immunoglobulin complex. We identified TAGs in every ST slide regardless of cancer type. Conclusions: These TAGs are enriched for ontology terms, illustrating the biological relevance to our image topology features and their potential utility in diagnostic and prognostic models.

Introduction: Minor oral surgical procedures are practiced in dental teaching. Interns are required to be competent, well-prepared and acknowledge its basics before their practice. Lack of training and knowledge could lead to serious consequences during clinical practice. Aim: To assess the knowledge and confidence level between male and female dental interns in private and governmental Riyadh dental schools in performing simple dento-alveolar procedures. Materials and Methods: A cross-sectional observational study was conducted at Princess Nourah bint Abdulrahman University in Riyadh, Saudi Arabia in January 2020 among dental interns from all Riyadh dental schools. A cross-sectional survey containing 23 items was used. The first part included the informed consent and demographic data (item 1-3). The second part consisted of 10 case scenarios to assess the knowledge level (item 4-13), and the third part was developed to self-rate their confidence level (item 14-23). Around 300 participants belonging to five Riyadh dental schools comprised the study population. All interns were included in the study after obtaining informed consent. All statistical analyses were performed using Statistical Package for the Social Sciences (SPSS) version 21.0 and Microsoft Excel 16.16. Groups were compared using Pearson chi-square and unpaired sample t-test. The p-value of <0.05 was considered statistically significant. Results: Out of 300 interns invited to participate, 210 submitted the electronic survey (70%). The final study population included 117 (56%) females and 93 (44%) males. A total of 111 (53%) belonged to governmental college, and 99 (47%) belonged to private college. There was no statistically significant difference between females and males in total knowledge (p<0.272) and confidence score (p<0.850), respectively. However, a statistically significant difference in knowledge and confidence between government and private colleges was found (p<0.001). A weakly positive significant correlation (r=0.217, p=0.002) was found between the total score of knowledge and the total score of confidence in performing surgical procedures. Conclusion: The study provides baseline data on the knowledge and perceived confidence of dental interns in Saudi Arabia about certain clinical procedures in oral surgery, where respondents were most knowledgeable in prescribing an appropriate medication. They were confident in giving effective local anaesthesia. All in all, interns had a superficial knowledge about the classification of impacted teeth and they were least confident in managing cases of an intraoral abscess.