Antibiotics are lifesaving therapeutic drugs that have been used by human for decades. They are used both in the fight against bacterial pathogens for both human and for animal feeding. However, of recent, their effects on the gut microbial compositions and diversities have attracted much attention. Existing literature have established the dysbiosis (reduced diversity) in the gut microbiota in association with antibiotic and antibiotic drug doses. In the light of spelling out the varying effects of antibiotic use on gut microbiota, this review aimed at given an account on the degree of gut microbial alteration caused by common antibiotics. While some common antibiotics are found to destroy the common phyla, other debilitating effects were observed. The effects can be attributed to the mode of mechanism, the class of antibiotic, the degree of resistance of the antibiotic used, the dosage used during the treatment, the route of administration, the pharmacokinetic and pharmacodynamics properties and the spectrum of the antibiotic agent. Health status, stress or the type of diet an individual feeds on could be a great proportion as confounding factors. While it is understood that only the bacterial communities are explored in the quest to establishing the role of gut in health, other gut microbial species are somehow contributing to the dysbiosis status of the gut microbiota. Until now, long term natural fluctuations like diseases outbreaks and mutations of the strain might as well rendered alteration to the gut independent of antibiotic treatments.
Resistance to penicillin and ciprofloxacin increased greatly during 1996-2001. Ceftriaxone and spectinomycin should be used as the first line agents in treating gonorrhoea. It is of great importance to continuously survey the susceptibilities of N gonorrhoeae to antibiotics in controlling the spread of gonococcal infections.
In the process of production and operation of family farms, a large amount of agricultural waste, such as livestock and poultry manure, has not been effectively treated in time, causing serious pollution to the environment. Moreover, livestock and poultry manure are the kind of resources that can be recycled to fertilize crops, which can benefit family farms both economically and environmentally. Adoption of manure biogas digesters by family farms can improve sustainability by not only decreasing input use and resource losses, but also reducing environmental pollution. Additionally, Material Flow Cost Accounting (MFCA) is considered to be the most representative environmental management accounting tool. MFCA can be expanded to account for and calculate environmental damages, so as to better reflect the economic and environmental sustainability of agricultural systems. According to the basic principles of material flow cost accounting and characteristics of family farms, we propose an agricultural-waste-recycling model for Chinese family farms that is based on the extended MFCA in this paper. We first investigate Chinese family farms in Hunan Province, and then optimize an agricultural-waste-recycling model by extended MFCA. Finally, based on our proposed model, we make a two-dimensional analysis on the internal resource cost and external environment damages for agricultural-waste recycling. Our analysis shows that visualization of monetization of resource losses can optimize manure recycling through better decision-making, which can increase the sustainability of family farms.
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