The present article aimed to evaluate the drug therapy applied to patients who were followed up for SARS-CoV-2, and who were tested positive and negative 2019-nCov. Material and Methods:A comprehensive and systematic literature search of numerous electronic databases regarding patients SARS-CoV-2 was performed.Results: Patients with 2019-nCoV can be treated with ceftriaxone, moxifloxacin, oseltamivir, hydroxychloroquine, and patients with poor prognosis can also be given lopinavir/ritonavir. Conclusions: Not only rRT-qPCR test results and CT findings but also clinical evidence should be considered for the diagnosis of SARS-CoV-2.

We read the article ''Association Between Coronary Artery Ectasia and Neutrophil-Lymphocyte Ratio'' by Balta et al 1 with interest. The authors 1 evaluated the neutrophil-tolymphocyte (N/L) ratio in patients with coronary artery ectasia (CAE). The N/L ratio and mean platelet volume (MPV) levels were significantly higher in both CAE and coronary artery disease (CAD) groups compared with the control group. However, there was no significant difference in the N/L ratio and the MPV levels among the subgroups of CAE and between CAE and CAD groups. 1 We would like to make a few comments.The incidence of CAE varies from 1.5% to 5%, and its pathogenesis is unclear. However, a number of local and systemic abnormalities including atherosclerosis, endothelial dysfunction, and systemic inflammation have been reported. 2 Additionally, atherosclerosis is an inflammatory response to a variety of traditional risk factors. Therefore, new studies have focused on inflammatory markers to determine their importance in cardiovascular disease including CAE. The N/L ratio represents the balance between neutrophil and lymphocyte counts. Most of conditions including traditional risk factors (ie, hypertension, atherogenic lipoproteins, and hyperglycemia) and many other inflammatory conditions (ie, infection and chronic renal failure) can change this ratio. 3 The glomerular filtration rate (GFR) provides more sensitive information about renal function than the serum creatinine level. 4 The GFR can be measured via the formula of modification of diet in renal disease and Cockcroft-Gault equation. 4 Renal dysfunction from stages 1 to 5 is an ongoing systemic inflammatory process, and most of the large-scale studies investigating inflammatory markers have recommended the calculation of GFR. 4 However, in this study, the authors 1 defined the exclusion criteria with a serum creatinine level >1.5 mg/dL, which is insufficient for renal dysfunction.In addition, the authors 1 did not analyze markers of inflammation such as C-reactive protein (CRP), although the role of inflammation was previously reported in those patients. If the CRP levels of these patients had been screened and correlated with the N/L ratio, it would provide a better perspective. Recently, the same group has reported that the N/L ratio without other inflammatory markers may not provide information to clinicians about chronic endothelial inflammation. 5 Despite

OBJECTIVE: Diabetic foot ulcers are the most common cause of hospitalization among the diabetic complications. Hemoglobin A1C (HbA1C) has a critical role in medical follow-up of diabetic patients. In fact, the role of HbA1C and related clinical parameters has been investigated in literature there are only a few studies investigating the relationship between HbA1C and the prolonged antibiotherapy. We aim to reveal the reciprocal relationship between this two parameters. METHODS: The clinical data of 139 patients who admitted with diabetic foot ulcers are analyzed retrospectively. Besides the demographic information, the levels of HbA1C wound localizations, the degree of the wounds regarding the Wagner classification, culture antibiogram, and the duration of the antibiotic agents. The data have been analyzed with IBM SPSS Statistics (IBM Statistical Package for the Social Sciences) for Windows 22.0. RESULTS: The clinical data of the 139 diabetic foot patients are retrospectively assessed. The mean age was 56.50 (±4.12). There were 81 male (58.27%) and 58 (41.73%) female patients. The distal type diabetic foot ulcers were found to be the most frequent type (n=83, 59.71% [±3.12]). The mean HbA1C level was 9.60 (±1.10). The “7–15%” subgroups of HbA1C level patients showed statistically significant prolongation of the antibiotherapy time (p<0.01). CONCLUSION: The results showed that the higher levels of HbA1C have a significant effect on treatment duration and formation of deeper and larger wounds with advanced stages of Wagner classification. This result may reveal the importance of the exact starting time of the treatment besides the proper glycemic control. Lager scaled studies may clarify the credited parameters related to diabetic foot ulcers for a reinterpretation of the issue.

No abstract

No abstract