A novel near-infrared phosphorescent iridium(iii) complex was developed for fast and highly specific peroxynitrite detection through the use of time-resolved emission spectra.

A base-promoted and metal-/oxidant-free one-pot three-component tandem annulation of amidines, aryl/alkyl isothiocyanates, and α-bromoesters/ketones to 2,4,5-trisubstituted thiazoles is described. This operationally simple protocol involves a base-promoted CÀ N bond cleavage of amidines and features readily available starting materials, excellent functional group tolerance, and high step-economy. It leads to the preparation of 2,4,5-trisubstituted thiazoles efficiently and has potential applications in the field of drug screening and modification.[a] Prof.