The association of thrombotic microangiopathy (TMA) with systemic lupus erythematosus (SLE) has been described in 0.5 to 10% of cases, and patients present worse outcome. TMA is described as the association of microangiopathic hemolytic anemia, thrombocytopenia, and an organ injury, frequently the kidney. This study describes a successful case of use of eculizumab in a patient with SLE and TMA refractory to standard therapy, and provides a literature review. Case description and search in PubMed and MEDLINE using systemic lupus erythemathous and/or antiphospholipid syndrome (APS) and eculizumab retrieved 15 case reports. Eighteen-year-old female presented acute renal failure and TMA and was diagnosed with SLE. Steroids and IV cyclophosphamide were started together with plasma exchange. After 55 days, she still persisted with microangiopathic anemia, thrombocytopenia, and anuria, and eculizumab was introduced. She had rapid improvement in hematological parameters, and dialysis was discontinued 25 days after the first dose. Genetic analysis showed large heterozygous deletion encompassing the entire CFHR1 and CFHR3, a finding previously associated with patients presenting atypical hemolytic-uremic syndrome (aHUS). Twenty patients who received eculizumab with SLE and/or APS have been published to date: 11 were female and mean age at presentation was 31 years. Seven out of the 20 patients presented only SLE, 5 patients only APS and 8 patients both SLE and APS. Eighteen patients underwent plasma exchange, with a mean of 20 (4-120) sessions per patient. Thirteen patients received rituximab. Hematological response was evident in 100% and kidney recovery in 85% of patients. The terminal complement blockade with eculizumab is an optional treatment for patients with SLE and/or APS presenting TMA and refractory to current immunosuppression therapies. Genetic testing may help recognize patients with aHUS and SLE/APS and therefore help to determine length of treatment with eculizumab.

Independent Learning Independent Campus (MBKM) was launched by the Ministry of Education, Culture, and Research and Technology to support the readiness of students to face challenges in the world of work by applying active learning. Documentary institutions in universities, namely libraries, archives, and museums, should become strategic partners in supporting the MBKM program because the documentary institution has all the necessary conditions, facilities, and infrastructure to succeed MBKM program. This study aimed to determine the readiness of documentary institutions in the university environment to exploit the opportunities and challenges and what obstacles they encountered. This study used the qualitative method and in-depth interviews for data collection and a literature study. The researcher concludes that the biggest challenges facing documentary institutions are regulation and the readiness of human resources. Due to this, changes to regulations and educational curricula and the introduction of new documentation of pure science are priorities in improving professional education providers in library science, archives, and museology.

This study demonstrated that the presence of HLA-DRB1*15 was a strong factor that predisposed patients to the development of SLE and LN, but did not influence kidney graft survival.

Penelitian ini membahas tentang pemanfaatan Line Today terhadap pemenuhan kebutuhan informasi mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro Semarang yang bertujuan untuk mengetahui hubungan antara pemanfaatan Line Today terhadap pemenuhan kebutuhan informasi mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro Semarang berdasarkan 4 indikator teori Usability oleh Rubin dan Chisnell dan 4 indikator pendekatan kebutuhan informasi oleh Guha. Metode penelitian yang digunakan adalah kuantitatif deskriptif dengan teknik pengambilan data menggunakan kuesioner. Populasi dalam penelitian ini adalah 2.763 mahasiswa dengan sampel sebanyak 310 responden yang ditentukan menggunakan proportionate stratified random sampling. Analisis data menggunakan analisis deskriptif dengan hasil penelitian yang menunjukkan bahwa terdapat hubungan positif yang sangat kuat sebesar 0,809 antara pemanfaatan Line Today dengan pemenuhan kebutuhan informasi mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro Semarang. Uji hipotesis dilakukan dengan menganalisis hasil koefisien korelasi Pearson Product-Moment antara variabel pemanfaatan Line Today dengan variabel pemenuhan kebutuhan informasi. Hasilnya didapatkan nilai signifikansi sebesar 0,000. Kriteria penolakan H0 adalah jika nilai signifikan α < 0,05, sehingga Ha diterima dan H0 ditolak karena diperoleh nilai signifikansi yang lebih kecil dari 0,05. Maka dapat disimpulkan bahwa Line Today dimanfaatkan untuk memenuhi kebutuhan informasi mahasiswa Fakultas Ilmu Budaya Universitas Diponegoro Semarang.

Title: Opportunities and Challenge of the Implementation of Cloud Computing as an automation solution in cooperation between libraries]Cloud computing is not something new. Nevertheless the potential utilization is not fully realized by the wider community, especially its potential to become a means of automation of cooperation between libraries. Availability of infrastructure vendors, web-based library software, to web browsers that have been popular among the community is the initial capital to implement cloud computing in various library services. Although on the other side, the library must face challenges such as the utilization of human resources in the library as a manager of the library system itself, as well as investment in the development of cloud computing platform. These challenges can be overcome by building cooperation, both internally with fellow libraries, as well as by encouraging government and enterprise support in the field of information and communication technology. AbstrakCloud Computing atau komputasi awan bukanlah sesuatu hal yang baru. Meskipun demikian potensi pemanfaatannya belum sepenuhnya disadari oleh masyarakat luas, terlebih potensinya untuk menjadi sarana automasi kerjasama antar perpustakaan. Ketersediaan vendor infrastruktur, software perpustakaan berbasis web, hingga web browser yang telah populer di kalangan masyarakat merupakan modal awal untuk mengimplementasikan komputasi awan pada berbagai layanan perpustakaan. Meskipun di lain sisi perpustakaan harus menghadapi tantangan seperti pendayagunaan SDM dalam perpustakaan sebagai pengelola sistem perpustakaan itu sendiri, serta investasi dalam pembangunan platform komputasi awan. Tantangan-tantangan tersebut dapat diatasi dengan membangun kerjasama, baik secara internal dengan sesama perpustakaan, maupun dengan mendorong dukungan pemerintah serta perusahaan-perusahaan dalam bidang teknologi informasi dan komunikasi.