Colorimetric indicator gels were developed by incorporating anthocyanin (AC) obtained from red cabbage into poly (ethylene glycol) diacrylate (PEGDA)-based hydrogel containing lignocellulose nanofiber (LCNF). The PEGDA-based hydrogel was prepared by mixing all of the mentioned components at the specific composition, and the hydrogels were cured under UV light (245 nm) for 1 min. The pH-response, UV absorption, swelling ratio, and mechanical properties of PEGDA/LCNF were determined. It was further found that PEGDA and LCNF mount play an important role in adjusting the mechanical properties of PEGDA/LCNF. In general, the presence of LCNF improved the mechanical properties and swelling ratio of PEGDA. The incorporation of red cabbage anthocyanin into the PEGDA/LCNF film showed multicolor response when specific pH buffers were introduced. Based on the multicolor response of PEGDA/LCNF/CA, this gel film indicator can be developed as a food freshness indicator that focuses on the detection of ammonia and amine compound.
Ilalang (Imperata cylindrica L) merupakan tumbuhan liar yang jarang dimanfaatkan. Daun ilalang mengandung senyawa bioaktif seperti alkaloid dan flavonoid. Senyawa flavonoid dapat digunakan sebagai zat reduktor alami dalam sintesis nanopartikel perak (AgNPs). Tujuan pada penelitian ini adalah sintesis nanopartikel perak menggunakan bioreduktor alami dari ekstrak daun ilalang. Sintesis nanopartikel perak menggunakan metode green synthesis (reduktor alam). Terbentuknya koloid nanopartikel perak terlihat secara visual ditandai dengan perubahan warna koloid menjadi coklat setelah penambahan ekstrak daun ilalang. Hasil UV-Vis menunjukkan nanopartikel perak memiliki puncak serapan pada panjang gelombang 420 nm dengan nilai absorbansi 1,9. FTIR memperlihatkan spektrum pengurangan puncak serapan nanopartikel perak pada bilangan gelombang 3356 cm-1. Hasil XRD dan PSA menunjukkan nanopartikel perak memiliki rata-rata ukuran kristal 19 nm dan distribusi ukuran partikel sebesar 1160 nm. Nanopartikel perak memiliki bentuk bulat dengan ukuran partikel 20 nm yang terlihat pada morfologi hasil TEM
Application of stimuli-responsive star polymers in cancer targeting and drug delivery has been extensively researched because of their several advantages in comparison with their linear counterparts. Functionalization and recombination of various arm architectures of the star polymer are very possible to be conducted to suit various needs. The star polymers could not only load more therapeutic drug due to more arms than linear polymers but also be functionalized with targeted moieties for more targeted delivery. Furthermore, the chains in star polymers could be regulated to produce stimuli-responsive star polymer for cancer targeting. The review article aimed to describe the benefits of star polymers and the types of stimuli-responsive delivery system for cancer targeting. Over the last decade, stimuli-responsive star polymers for cancer targeting using either internal stimuli (e.g., pH, redox, enzyme, hypoxia) or external stimuli (e.g., thermal, ultrasound, light, magnetic) has garnered immense interest for researchers. Possibility to mimic a complex natural phenomenon could be achieved by incorporating various stimuli-responsive functionalities in the star polymer.
Hand sanitizers, handsoaps, and disinfectants (H2D) have become necessities in a new normal during the Covid-19 pandemic. These three items are necessary to use in daily activities to prevent the spread of Covid-19. One of the efforts to successfully adopt a new normal is to educate the youth on preventing the spread of Covid-19. Workshop and education on making simple H2D at SMK Negeri 3 Kotabumi have been held through outreach activities and hands-on practice. The goal of this activity is to increase the students knowledge of SMK Negeri 3 Kotabumi in living a new lifestyle to prevent the spread of Covid-19 in North Lampung Regency. The result of this educational program is an increase in the knowledge of students of SMK Negeri 3 Kotabumi about H2D in terms of composition, making, and use. Besides, through the workshop program, students of SMK Negeri 3 Kotabumi also acquire skills in making simple H2D. Through presentation and direct practice, students of SMK Negeri 3 Kotabumi have been educated to become new lifestyle agents to prevent the spread of Covid-19 in North Lampung Regency.
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