Purpose To evaluate the peripapillary retinal nerve fiber layer (RNFL) thickness measured with spectral‐domain optical coherence tomography (OCT) in obstructive sleep apnea syndrome (OSA) patients, as a biological marker of neuronal damage. Methods Sixty‐four OSA patients and one hundred twenty‐nine healthy controls were consecutive and prospectively selected. Only one eye per subject was randomly chosen. AOS patients were classified in three groups according to apnea/hipopnea index: mild, moderate and severe. All participants performed a comprehensive ophthalmologic examination and at least a reliable standard automated perimetry (SAP). Peripapillary RNFL thicknesses were measured with the Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). After checking for a normal distribution of variables, differences between both groups were tested by Student t test. Results Age was 50.6 ± 9.3 years in control eyes and 47.8 ± 11.5 years in AOS patients (p = 0.09). Mean deviation of SAP was ‐0.50 ± 1.0 dB and ‐1.4± 2.3 dB, in control and AOS patients, respectively (p<0.001). Pattern standard deviation and Visual Field Index (VFI) of SAP were also different between both groups. The RNFL thickness at temporal superior segment and the superior segment had lower thicknesses in AOS patients compared to healthy individuals. Conclusion OCT detected a mild reduction of RNFL thickness in AOS patients compared with healthy subjects. Visual field indices were also different between both groups.

Purpose To determine the reproducibility and repeatability of retinal nerve fiber layer parameters measured using scanning laser polarimetry (SLP) with enhanced corneal compensation (GDx‐ECC) in glaucoma patients. Methods Fifty‐four consecutive glaucomatous subjects were prospectively selected. All participants underwent a comprehensive eye exam and at least a reliable standard automated perimetry (Humphrey, 24‐2 SITA Standard). Only one eye per patient was randomly included in the statistical analysis. Three scans were acquired during the same visit using the GDxPRO (Carl Zeiss Meditec, Dublin, CA). Two additional scans were obtained within a 2‐month period. Intraclass correlation coefficient (ICC), coefficient of variation (COV), and test‐retest variability were calculated for all SLP parameters. Results Mean age was 58.27 ± 8.9 years (p=0.09) and mean deviation of standard automated perimetry was ‐7.04 ± 7.0 dB. ICCs were higher than 0.91 for all SLP parameters. The nerve fiber indicator (NFI) showed the highest ICC in the intra‐test sequence (0.982; 95% confidence interval: 0.972‐0.989; p<0.001). The TSNIT average showed the lowest COVs (4.40% and 4.71% in the intra‐ and inter‐test, respectively). Test‐retest variability for the NFI ranged from 10.6 to 12.8. Conclusion The GDx‐ECC had an excellent intravisit and intervisit reproducibility in glaucoma patients. SLP is an imaging technology that may be useful in monitoring glaucoma progression. Commercial interest

Purpose To present a case report of a patient with congenital glaucoma and megalocornea, who suffer iris desinsertion and crystalline luxation during adulthood. Methods We present a 46‐year‐old male with bilateral congenital glaucoma treated with bilateral goniotomy in pediatric age and right eye (RE) blind after a traumatism. He refered visual acuity (VA) loss in his left eye (LE). The visual acuity was light perception in RE and count fingers at 50 cm in LE. Ophthalmological exams evidenced asymmetric bilateral buphthalmos. The LE shows 21 mm of diameter corneal, transparent cornea, severe iridodonesis, 360º iris desinsertion, afaquia, and 22 mmHg of intraocular pressure by applanation tonometry. This eye was treated with dorzolamide and timolol maleate. Posterior luxation of the crystalline was found in the ophthalmic ultrasound. Results A +14 diopters lens provided the best corrected visual performance achievable of 0.05 with LE. Non‐invasive treatment was selected in order to avoid surgery complications. Conclusion Ophthalmologists should to monitor intraocular pressure and corneal diameter in patients with congenital glaucoma because increase in corneal diameter is a biomarker of progression of glaucoma. In these patients, interdisciplinary valuation of systemic and ophthalmological findings should be performed.