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This study was conducted to evaluate the in vitro polyphenol content, antioxidant, cytotoxic, antibacterial, anthelmintic properties, and in vivo antinociceptive activity of the ethanol extract of Cissus adnata leaves (EECA) in different experimental models. Polyphenol contents were investigated using spectrophotometric techniques. Antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) radical-scavenging, ferric reducing power, and total antioxidant capacity assays. Cytotoxicity was determined by brine shrimp lethality bioassay and disc diffusion method was used for the antibacterial activity. Anthelmintic activity was studied using aquarium worm (Tubifex tubifex) whereas antinociceptive activity was evaluated in mice by acetic acid and formalin test. Phytochemical screening of EECA revealed the presence of alkaloids, carbohydrates, flavonoids, phenols, terpenoids, saponins, and tannins. EECA showed strong antioxidant activity with high polyphenol contents. It was observed that EECA possessed significant antibacterial activity with a low toxicity profile. EECA also demonstrated dose-dependent and statistically significant anthelmintic and antinociceptive activities. Our study shows that ethanol extract of C. adnata leaves possess strong antioxidant, antibacterial, anthelmintic and antinociceptive activities with lower toxicity. Further studies are needed to identify bioactive phytomolecules and to understand the mechanism of such actions better.

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including antioxidants finds increased use in the treatment of such diseases. This has stimulated the production of patented antioxidant preparations based on various components of natural or synthetic origin. The use of natural antioxidants for the treatment and prophylaxis of free radical induced pathologies has certain advantages. Most of these agents produce no side effects, possess low toxicity, and effectively act upon the main factors damaging the vascular system. Plants (fruits, vegetables, medicinal herbs) contain a wide variety of free radical scavenging molecules, such as phenolic compounds, nitrogen compounds, vitamins, terpenoids and some other endogenous metabolites, that are rich in antioxidant activity [3,4,5,6]. Diabetes is also the fourth-leading cause of death [7]. The diabetic population is rapidly increasing globally, particularly in the developing countries. South Asian region including Bangladesh is the most vulnerable focus. The current worldwide diabetic population is about 150 million and this will be doubled by 2025 [8]. The estimated prevalence of diabetes in Bangladesh is around 4%, which is similar to the average prevalence in many

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