Antioxidant, Analgesic and Anti-inflammatory Activities of the Herb Eclipta prostrata

Hossain, Sajjad; Alam, M. Badrul; Chowdhury, Nargis Sultana; Asadujjaman, M; Zahan, Ronok; Islam, M.R.; Mazumder, M. Ehsanul Haque; Haque, Ekramul; Islam, A. K. M. Saiful

doi:10.3923/jpt.2011.468.480

Cited by 25 publications

(17 citation statements)

References 30 publications

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“…Pain is an unpleasant sensory and emotional experience associated with potential tissue damage. The action of chemical mediators such as PG, leucotrienes, peptides, acetylcholine, cytokines, nitric oxide, serotonin etc, produced or released during tissue injury or exogenous irritants (viz., formalin, acetic acid) are able to stimulate nociceptors, induce pain and are responsible for multiplicity of events that occur during pain transmission, in both peripheral and central nervous system (Le Bars et al, 2001;Bhaskar and Balakrishnan, 2009;Hossain et al, 2011;Kabir et al, 2012). Tail flick method is one of the widely used models to study analgesic activity of drugs.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

Prashith¹,

R²,

Raghavendra³

2013

Sci. Technol. Arts Res. J.

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In the present study, pharmacological activities antipyretic and CNS depressant activity of crude extract of isolated from Western Ghats soil of Agumbe, Karnataka, India have been studied. T isolate PO-178 was grown in starch casein nitrate broth medium. The culture filtrate was condensed to obtain crude extract. Anti-inflammatory, analgesic, antipyretic and CNS depressant activities of the crude extract were determined by Carrageenan edema, tail flick, yeast induced pyrexia and s The extract exhibited dose dependent anti depressant activity, however, the activities observed were lesser than st Further studies are under progress to recover pharmacologically active principles from the extract of Streptomyces species PO-178 and to determine their activities.

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Section: Discussionmentioning

confidence: 99%

Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

Prashith¹,

R²,

Raghavendra³

2013

Sci. Technol. Arts Res. J.

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“…The EtOAc extract shows the highest free radical scavenging potency when compared to methanolic and chloroform extracts because of its high content of phenols and flavonoids 32 . Moreover, the EtOAc extract could attenuate 6-OHDA-induced neuronal apoptosis by decreasing the Bax/Bcl-2 ratio and the caspase-3 activity, suggesting that the protective ef-fects of the EtOAc extract might be mainly due to its antioxidant property.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of ethyl acetate extract of Eclipta prostrata against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

Jaisin¹,

Ratanachamnong²,

Prachayasittikul³

et al. 2016

ScienceAsia

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ABSTRACT:Oxidative stress plays an important role in the pathogenesis of Parkinson's disease. The neurotoxin 6-hydroxydopamine initiates cellular oxidative stress which has been implicated in neurodegenerative conditions related to Parkinson's disease. Eclipta prostrata, also known as false daisy, is a plant belonging to the sunflower family. It is a rich source of phenolic compounds that confer the plant an antioxidant activity. In this study, we investigated the protective effects of ethyl acetate extract of E. prostrata against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Pretreatment with the ethyl acetate extract of E. prostrata before exposing the cells to 6-hydroxydopamine significantly increased cell survival and reduced intracellular reactive oxygen species formation in a concentrationdependent manner. In addition, the ethyl acetate extract of E. prostrata suppressed the Bax/Bcl-2 ratio and reduced caspase-3 activity, a key modulator of cell apoptosis. Our finding clearly shows that the ethyl acetate extract of E. prostrata possesses a potential antioxidant capacity and attenuates SH-SY5Y cell death by blocking apoptotic signalling caused by 6-hydroxydopamine. E. prostrata could therefore be used as a potential herb to prevent oxidative stress-induced neurodegeneration in Parkinson's disease.

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“…Various endogenous mediators such as histamine, serotonin, bradykinin, prostaglandins, etc are most abundant in inflammatory cells and among them prostaglandins are ubiquitous substances that indicate and modulate cell and tissue responses involved in pain and inflammation. [5][6] The inflammatory agents exhibit therapeutic properties by blocking the action or synthesis of these mediators. The most widely used medicines in modern practice are cyclooxygenase (COX) inhibitors i.e.…”

Section: Introductionmentioning

confidence: 99%

Peels of Citrus Fruits: A Potential Source of Anti-inflammatory and Anti-nociceptive Agents

Malleshappa¹,

Kumaran²,

Krishna³

et al. 2018

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Introduction: The present study was contemplated to evaluate the anti-inflammatory and analgesic potentials in peels of some commercially grown Citrus fruits of South India viz, Lime (Citrus aurantifolia), Orange (Citrus reticulata), Sour Orange (Citrus aurantium), Pomello (Citrus grandis) and Citron (Citrus medica). Methods: The peel of the fruits were separated and subjected to cold extraction using 70% alcohol. The extracts obtained were screened for the presence of phytoconstituents by qualitative phytochemical analysis; the anti-inflammatory activity of extracts at 250 and 500mg/Kg body weight concentrations were assessed by in vivo Carrageenan induced rat paw edema model and in vitro HRBC membrane stabilization assay whereas Tail immersion and Hot plate methods have been used to evaluate their analgesic property. Results: The results revealed that, all extracts treated animals have shown significant decrease in paw edema volume at 3 rd and 4 th hour of treatment and increase in reaction time in tail immersion and hot plate readings at 120 and 150 min and are comparable to the standards. From the results it was evident that Citron peel extract exhibited significant antiinflammatory and analgesic property in all models. Preliminary phytochemical investigation revealed that extracts were bestowed with presence of flavonoids, terpenoids, steroids, glycosides, alkaloids, carotenoids and phenolic compounds which might be responsible for the antinociceptive and anti-inflammatory activities. Conclusion: From the results it was evident that all citrus fruits have prominent activity in terms of parameters assessed in a dose dependent manner and are more effective in the later phase. The study thus documents that Citrus peels are good sources of anti-inflammatory and anti-nociceptive agents.

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Antioxidant, Analgesic and Anti-inflammatory Activities of the Herb Eclipta prostrata

Cited by 25 publications

References 30 publications

Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

Protective effects of ethyl acetate extract of Eclipta prostrata against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

Peels of Citrus Fruits: A Potential Source of Anti-inflammatory and Anti-nociceptive Agents

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